TY - JOUR
T1 - Metabonomics and toxicology
AU - Zhao, Liang
AU - Hartung, Thomas
N1 - Publisher Copyright:
© Springer Science+Business Media New York 2015.
PY - 2015
Y1 - 2015
N2 - Being an emerging field of “omics” research, metabonomics has been increasingly used in toxicological studies mostly because this technology has the ability to provide more detailed information to elucidate mechanism of toxicity. As an interdisciplinary field of science, metabonomics combines analytical chemistry, bioinformatics, statistics, and biochemistry. When applied to toxicology, metabonomics also includes aspects of patho-biochemistry, systems biology, and molecular diagnostics. During a toxicological study, the metabolic changes over time and dose after chemical treatment can be monitored. Therefore, the most important use of this emerging technology is the identification of signatures of toxicity—patterns of metabolic changes predictive of a hazard manifestation. This chapter summarizes the current state of metabonomics technology and its applications in various areas of toxicological studies.
AB - Being an emerging field of “omics” research, metabonomics has been increasingly used in toxicological studies mostly because this technology has the ability to provide more detailed information to elucidate mechanism of toxicity. As an interdisciplinary field of science, metabonomics combines analytical chemistry, bioinformatics, statistics, and biochemistry. When applied to toxicology, metabonomics also includes aspects of patho-biochemistry, systems biology, and molecular diagnostics. During a toxicological study, the metabolic changes over time and dose after chemical treatment can be monitored. Therefore, the most important use of this emerging technology is the identification of signatures of toxicity—patterns of metabolic changes predictive of a hazard manifestation. This chapter summarizes the current state of metabonomics technology and its applications in various areas of toxicological studies.
KW - Mass spectrometry
KW - Mechanism of toxicity
KW - Metabonomics/metabolomics
KW - Omics technology
KW - Pathways of toxicity
KW - Systems biology
KW - Toxicology
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U2 - 10.1007/978-1-4939-2377-9_15
DO - 10.1007/978-1-4939-2377-9_15
M3 - Article
C2 - 25677156
AN - SCOPUS:84922954394
SN - 1064-3745
VL - 1277
SP - 209
EP - 231
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
ER -