Metabolomics and incidence of atrial fibrillation in African Americans: The atherosclerosis risk in communities (ARIC) study

Alvaro Alonso, Bing Yu, Waqas T. Qureshi, Morgan Grams, Elizabeth Selvin, Elsayed Z. Soliman, Laura R. Loehr, Lin Y. Chen, Sunil K. Agarwal, Danny Alexander, Eric Boerwinkle

Research output: Contribution to journalArticle

Abstract

Background Atrial fibrillation (AF) is a common arrhythmia. Application of metabolomic approaches, which may identify novel pathways and biomarkers of disease risk, to a longitudinal epidemiologic study of AF has been limited. Methods We determined the prospective association of 118 serum metabolites identified through untargeted metabolomics profiling with the incidence of newly-diagnosed AF in 1919 African- American men and women from the Atherosclerosis Risk in Communities study without AF at baseline (1987-1989). Incident AF cases through 2011 were ascertained from study electrocardiograms, hospital discharge codes, and death certificates. Results During a median follow-up of 22 years, we identified 183 incident AF cases. In Cox proportional hazards models adjusted for age, sex, smoking, body mass index, systolic blood pressure, use of antihypertensive medication, diabetes, prevalent heart failure, prevalent coronary heart disease, and kidney function, two conjugated bile acids (glycolithocholate sulfate and glycocholenate sulfate) were significantly associated with AF risk after correcting for multiple comparisons (p

Original languageEnglish (US)
Article numbere0142610
JournalPLoS One
Volume10
Issue number11
DOIs
StatePublished - Nov 6 2015

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Metabolomics
metabolomics
African Americans
atherosclerosis
Atrial Fibrillation
Atherosclerosis
incidence
Sulfates
Incidence
Blood pressure
Biomarkers
Medical problems
Metabolites
Bile Acids and Salts
Electrocardiography
Antihypertensive Agents
Hazards
Association reactions
sulfates
Blood Pressure

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Metabolomics and incidence of atrial fibrillation in African Americans : The atherosclerosis risk in communities (ARIC) study. / Alonso, Alvaro; Yu, Bing; Qureshi, Waqas T.; Grams, Morgan; Selvin, Elizabeth; Soliman, Elsayed Z.; Loehr, Laura R.; Chen, Lin Y.; Agarwal, Sunil K.; Alexander, Danny; Boerwinkle, Eric.

In: PLoS One, Vol. 10, No. 11, e0142610, 06.11.2015.

Research output: Contribution to journalArticle

Alonso, A, Yu, B, Qureshi, WT, Grams, M, Selvin, E, Soliman, EZ, Loehr, LR, Chen, LY, Agarwal, SK, Alexander, D & Boerwinkle, E 2015, 'Metabolomics and incidence of atrial fibrillation in African Americans: The atherosclerosis risk in communities (ARIC) study', PLoS One, vol. 10, no. 11, e0142610. https://doi.org/10.1371/journal.pone.0142610
Alonso, Alvaro ; Yu, Bing ; Qureshi, Waqas T. ; Grams, Morgan ; Selvin, Elizabeth ; Soliman, Elsayed Z. ; Loehr, Laura R. ; Chen, Lin Y. ; Agarwal, Sunil K. ; Alexander, Danny ; Boerwinkle, Eric. / Metabolomics and incidence of atrial fibrillation in African Americans : The atherosclerosis risk in communities (ARIC) study. In: PLoS One. 2015 ; Vol. 10, No. 11.
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