Metabolites in ventrilcular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging

Lidia M. Nagae-Poetscher, Michael McMahon, Nancy Braverman, William T. Lawrie, Ali Fatemi, Mahaveer Degaonkar, Alena Horská, Martin G. Pomper, Vaddapuram P. Chacko, Peter B. Barker

Research output: Contribution to journalArticle

Abstract

Normally, ventricular cerebrospinal fluid (CSF) contains low levels of all metabolite signals on proton magnetic resonance spectroscopic imaging (MRSI). We present here three cases (two with seizure disorders, one with a central nervous system lymphoma) who presented with unusually elevated CSF signals on MRSI. Based on chemical shifts and in vitro studies (in one case), the signals were assigned to propan-1,2-diol (PD), acetone, and lactate, respectively. These compounds were either exclusively, or more readily, detected in CSF than in brain. Proton MRSI conveniently screens both brain and CSF for abnormal metabolism simultaneously.

Original languageEnglish (US)
Pages (from-to)496-500
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume20
Issue number3
DOIs
StatePublished - 2004

Keywords

  • Acetone
  • Brain
  • CSF
  • Lactate
  • Propan-1,2-diol
  • Spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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