Sulfatides, the 3′-sulfate esters of galactocerebrosides, are components of the mammalian myelin sheath. The synthesis of these lipids can be followed by measuring the incorporation of S35-sulfate into the lipid fraction of brain (Davison and Gregson, 1962). In the rat cerebrum, the period of active synthesis of sulfatides invivo (Davison and Gregson, 1962) and invitro (McKhann, et al, 1965) coincides with the onset of the histological appearance of myelin. Despite the close chemical similarity of galactocerebrosides and sulfatides, their metabolic relationships have not been established. The studies reported in this paper indicate that galactocerebrosides are sulfated by a soluble enzyme obtained from the microsomal fraction of rat brain.
|Original language||English (US)|
|Number of pages||5|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Jul 12 1965|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology