Metabolism of sulfatides. I. The effect of galactocerebrosides on the synthesis of sulfatides

G. M. McKhann, R. Levy, W. Ho

Research output: Contribution to journalArticlepeer-review

Abstract

Sulfatides, the 3′-sulfate esters of galactocerebrosides, are components of the mammalian myelin sheath. The synthesis of these lipids can be followed by measuring the incorporation of S35-sulfate into the lipid fraction of brain (Davison and Gregson, 1962). In the rat cerebrum, the period of active synthesis of sulfatides invivo (Davison and Gregson, 1962) and invitro (McKhann, et al, 1965) coincides with the onset of the histological appearance of myelin. Despite the close chemical similarity of galactocerebrosides and sulfatides, their metabolic relationships have not been established. The studies reported in this paper indicate that galactocerebrosides are sulfated by a soluble enzyme obtained from the microsomal fraction of rat brain.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume20
Issue number2
DOIs
StatePublished - Jul 12 1965

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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