Metabolism of epidoxorubicin in animals: absence of glucuronidation

P. A. Maessen; K. B. Mross; H. M. Pinedo; W. J F van der Vijgh

doi:10.1007/BF00252968

Metabolism of epidoxorubicin in animals: absence of glucuronidation

P. A. Maessen, K. B. Mross, H. M. Pinedo, W. J F van der Vijgh

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Abstract

Metabolism of epidoxorubicin was studied in plasma of seven different animal species at 2 h after administration of 4 mg/kg. None of the animals showed significant glucuronidation of epidoxorubicin, although small amounts of the glucuronides could be detected in the rabbit. However, large differences in formation of epidoxorubicinol and 7-deoxy (7d) doxorubicinol aglycone were observed between the species. These phenomena may be relevant for interspecies differences with regard to anthracycline-induced histomorphological changes in for example, heart tissues and cardiotoxicity in relation to formation of 7d aglycones.

Original language	English (US)
Pages (from-to)	85-87
Number of pages	3
Journal	Cancer Chemotherapy and Pharmacology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1007/BF00252968
State	Published - Aug 1987
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Oncology
Cancer Research

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abstract = "Metabolism of epidoxorubicin was studied in plasma of seven different animal species at 2 h after administration of 4 mg/kg. None of the animals showed significant glucuronidation of epidoxorubicin, although small amounts of the glucuronides could be detected in the rabbit. However, large differences in formation of epidoxorubicinol and 7-deoxy (7d) doxorubicinol aglycone were observed between the species. These phenomena may be relevant for interspecies differences with regard to anthracycline-induced histomorphological changes in for example, heart tissues and cardiotoxicity in relation to formation of 7d aglycones.",

author = "Maessen, {P. A.} and Mross, {K. B.} and Pinedo, {H. M.} and {van der Vijgh}, {W. J F}",

year = "1987",

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AU - Maessen, P. A.

AU - Mross, K. B.

AU - Pinedo, H. M.

AU - van der Vijgh, W. J F

PY - 1987/8

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AB - Metabolism of epidoxorubicin was studied in plasma of seven different animal species at 2 h after administration of 4 mg/kg. None of the animals showed significant glucuronidation of epidoxorubicin, although small amounts of the glucuronides could be detected in the rabbit. However, large differences in formation of epidoxorubicinol and 7-deoxy (7d) doxorubicinol aglycone were observed between the species. These phenomena may be relevant for interspecies differences with regard to anthracycline-induced histomorphological changes in for example, heart tissues and cardiotoxicity in relation to formation of 7d aglycones.

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Metabolism of epidoxorubicin in animals: absence of glucuronidation

Abstract

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