Metabolism of epidoxorubicin in animals: absence of glucuronidation

P. A. Maessen, K. B. Mross, H. M. Pinedo, W. J F van der Vijgh

Research output: Contribution to journalArticlepeer-review

Abstract

Metabolism of epidoxorubicin was studied in plasma of seven different animal species at 2 h after administration of 4 mg/kg. None of the animals showed significant glucuronidation of epidoxorubicin, although small amounts of the glucuronides could be detected in the rabbit. However, large differences in formation of epidoxorubicinol and 7-deoxy (7d) doxorubicinol aglycone were observed between the species. These phenomena may be relevant for interspecies differences with regard to anthracycline-induced histomorphological changes in for example, heart tissues and cardiotoxicity in relation to formation of 7d aglycones.

Original languageEnglish (US)
Pages (from-to)85-87
Number of pages3
JournalCancer Chemotherapy and Pharmacology
Volume20
Issue number1
DOIs
StatePublished - Aug 1987
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Oncology
  • Cancer Research

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