Metabolism of acetylcholine receptors in skeletal muscle.

D. M. Fambrough, P. N. Devreotes, D. J. Card, J. Gardner, K. Tepperman

Research output: Contribution to journalReview article

Abstract

The acetylcholine receptor in skeletal muscle is an integral plasma membrane glycoprotein. Its biosynthesis and incorporation into plasma membrane and its degradation are being studied with the use of biochemical, biophysical, and microscopic techniques. In this report, previously published data are combined with new information to yield a consistent and fairly detailed description ofthe mechanisms involved in receptor metabolism. It is proposed that the biosynthesis, transport, and incorporation of the receptor into plasma membranes involve a mechanism similar, or identical, to that used by the cell for production and secretion of secretory proteins. The receptor is degraded by a random-hit process, which involves internalization, transport to secondary lysosomes, and hydrolysis. Sites of regulation of receptor metabolism are discussed in the context of regulation of the number and distribution of receptors in plasma membranes, particularly with respect to the formation and stability of neuromuscular junctions.

Original languageEnglish (US)
Pages (from-to)277-294
Number of pages18
JournalNational Cancer Institute Monograph
Issue number48
StatePublished - May 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Metabolism of acetylcholine receptors in skeletal muscle.'. Together they form a unique fingerprint.

  • Cite this

    Fambrough, D. M., Devreotes, P. N., Card, D. J., Gardner, J., & Tepperman, K. (1978). Metabolism of acetylcholine receptors in skeletal muscle. National Cancer Institute Monograph, (48), 277-294.