Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human cytochrome P4501B1

Medicine & Life Sciences

• Cytochrome P-450 CYP1B1 100%
• 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine 89%
• hydroxide ion 50%
• 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine 18%
• Carcinogens 7%
• Cytochrome P450 Family 1 6%
• Dioxins 5%
• Fluorescence Spectrometry 5%
• Mutagens 4%
• Microsomes 4%
• Amines 4%
• Colonic Neoplasms 3%
• Mass Spectrometry 3%
• High Pressure Liquid Chromatography 3%
• Fluorescence 3%
• Yeasts 3%
• Colon 3%
• Carcinogenesis 3%
• Breast 3%
• Kinetics 2%
• Breast Neoplasms 2%
• Proteins 1%