Metabolism and aerobic capacity of skeletal muscle in chronic respiratory failure related to chronic obstructive pulmonary disease

B. Wuyam, J. F. Payen, P. Levy, H. Bensaidane, H. Reutenauer, J. F. Le Bas, A. L. Benabid

Research output: Contribution to journalArticlepeer-review

Abstract

The calf muscle energy metabolism of 8 stable chronic obstructive pulmonary disease (COPD) patients with chronic respiratory failure (arterial oxygen tension (PaO2) 7.7 ± 0.4 kPa or 58 ± 3 mmHg) was studied, using 31-phosphorus magnetic resonance spectroscopy (31P MRS). MRS spectra were acquired at rest and during the course of 360 pedal movements at 20, 35 and 50% of the maximal voluntary contraction (MVC) and during recovery. Eight healthy age-matched subjects served as the control group. No significant differences between groups were observed in resting muscle, as regards intracellular pH, Pi/PCr ratio (Pi: inorganic phosphate; PCr: phosphocreatine) and the relative ATP expressed as the ratio βATP/PCr+Pi+PME (PME: phosphomonoester). Although effective power outputs were similar for both groups at each work level, COPD patients exhibited a higher Pi/PCr ratio than healthy controls (3.34 ± 0.89 vs 0.49 ± 0.05 at 50% MVC; p < 0.01) and a lower pH(i) (6.65 ± 0.11 vs 7.06 ± 0.02 at 50% MVC; p < 0.01). PCr resynthesis during recovery was slower in patients than in control subjects (t( 1/2 ) PCr 1.27 ± 0.26 min vs 0.47 ± 0.05 min; p < 0.05). These results suggest impairment of aerobic capacity in a non-ventilatory working muscle, which may be due to hypoxaemia in patients with chronic respiratory failure.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalEuropean Respiratory Journal
Volume5
Issue number2
StatePublished - Jan 1 1992

Keywords

  • Chronic obstructive pulmonary disease
  • Energy metabolism
  • Exercise
  • Hypoxaemia
  • Magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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