TY - JOUR
T1 - Metabolic syndrome and osteoarthritis distribution in the hand joints
T2 - A propensity score matching analysis from the osteoarthritis initiative
AU - Mohajer, Bahram
AU - Kwee, Robert M.
AU - Guermazi, Ali
AU - Berenbaum, Francis
AU - Wan, Mei
AU - Zhen, Gehua
AU - Cao, Xu
AU - Haugen, Ida K.
AU - Demehri, Shadpour
N1 - Publisher Copyright:
© 2021 The Journal of Rheumatology.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Objective. To investigate the metabolic syndrome (MetS) association with radiographic and symptomatic hand osteoarthritis (HOA). Methods. Using 1:2 propensity score matching for relevant confounders, we included 2509 participants (896 MetS positive and 1613 MetS negative) from the Osteoarthritis Initiative dataset. MetS and its components, according to the International Diabetes Federation criteria, were extracted from baseline data, and included hypertension, abdominal obesity, dyslipidemia, and diabetes. We scored distinct hand joints based on the modified Kellgren-Lawrence (mKL) grade of baseline radiographs, with HOA defined as mKL ≥ 2. In the cross-sectional analysis, we investigated the association between MetS and its components with radiographic HOA and the presence of nodal and erosive HOA phenotypes using regression models. In the longitudinal analysis, we performed Cox regression analysis for hand pain incidence in follow-up visits. Results. MetS was associated with higher odds of radiographic HOA, including the number of joints with OA (OR 1.32, 95% CI 1.08–1.62), the sum of joints mKLs (OR 2.42, 95% CI 1.24–4.71), mainly in distal interphalangeal joints (DIPs) and proximal interphalangeal joints (PIPs; OR 1.52, 95% CI 1.08–2.14 and OR 1.38, 95% CI 1.09–1.75, respectively), but not metacarpophalangeal (MCP) and first carpometacarpal (CMC1) joints. Hand pain incidence during follow-up was higher with MetS presence (HR 1.25, 95% CI 1.07–1.47). The erosive HOA phenotype and joints’ nodal involvement were more frequent with MetS (OR 1.40, 95% CI 1.01–1.97 and OR 1.28, 95% CI 1.02–1.60, respectively). Conclusion. MetS, a potentially modifiable risk factor, is associated with radiographic DIP and PIP OA and longitudinal hand pain incidence while sparing MCPs and CMC1s. Nodal and erosive HOA phenotypes are associated with MetS, suggestive of possible distinct pathophysiology.
AB - Objective. To investigate the metabolic syndrome (MetS) association with radiographic and symptomatic hand osteoarthritis (HOA). Methods. Using 1:2 propensity score matching for relevant confounders, we included 2509 participants (896 MetS positive and 1613 MetS negative) from the Osteoarthritis Initiative dataset. MetS and its components, according to the International Diabetes Federation criteria, were extracted from baseline data, and included hypertension, abdominal obesity, dyslipidemia, and diabetes. We scored distinct hand joints based on the modified Kellgren-Lawrence (mKL) grade of baseline radiographs, with HOA defined as mKL ≥ 2. In the cross-sectional analysis, we investigated the association between MetS and its components with radiographic HOA and the presence of nodal and erosive HOA phenotypes using regression models. In the longitudinal analysis, we performed Cox regression analysis for hand pain incidence in follow-up visits. Results. MetS was associated with higher odds of radiographic HOA, including the number of joints with OA (OR 1.32, 95% CI 1.08–1.62), the sum of joints mKLs (OR 2.42, 95% CI 1.24–4.71), mainly in distal interphalangeal joints (DIPs) and proximal interphalangeal joints (PIPs; OR 1.52, 95% CI 1.08–2.14 and OR 1.38, 95% CI 1.09–1.75, respectively), but not metacarpophalangeal (MCP) and first carpometacarpal (CMC1) joints. Hand pain incidence during follow-up was higher with MetS presence (HR 1.25, 95% CI 1.07–1.47). The erosive HOA phenotype and joints’ nodal involvement were more frequent with MetS (OR 1.40, 95% CI 1.01–1.97 and OR 1.28, 95% CI 1.02–1.60, respectively). Conclusion. MetS, a potentially modifiable risk factor, is associated with radiographic DIP and PIP OA and longitudinal hand pain incidence while sparing MCPs and CMC1s. Nodal and erosive HOA phenotypes are associated with MetS, suggestive of possible distinct pathophysiology.
KW - Erosive osteoarthritis
KW - Hand
KW - Metabolic syndrome
KW - Nodal osteoarthritis
KW - Osteoarthritis initiative
KW - Propensity score matching
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U2 - 10.3899/jrheum.210189
DO - 10.3899/jrheum.210189
M3 - Article
C2 - 34329188
AN - SCOPUS:85116628008
SN - 0315-162X
VL - 48
SP - 1608
EP - 1615
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 10
ER -