Metabolic syndrome among adults living with sickle cell disease

Foluso Joy Ogunsile, Shawn M. Bediako, Julie Nelson, Cody Cichowitz, Tiffany Yu, C. Patrick Carroll, Kerry Stewart, Rakhi Naik, Carlton Haywood, Sophie Lanzkron

Research output: Contribution to journalArticlepeer-review

Abstract

Metabolic syndrome (MetS) is a key risk factor for cardiovascular disease (CVD) incidence and all-cause mortality. MetS prevalence among adults with sickle cell disease (SCD) is not well known. We report initial findings from a cross-sectional study that examined MetS risk factors within a cohort of adults living with SCD. 50 adult SCD participants (ages 21–66 years; 72% female) completed demographic and health behavior surveys, health-related family and personal histories, and anthropometric and laboratory measurements. Descriptive and inferential statistics were used to summarize and compare CVD risk factors, stratified in separate analyses by SCD genotype and sex. Triglyceride, blood pressure, and fasting glucose levels were within normal limits. 78% of the cohort reported moderate to high physical activity. However, 46% of this cohort was overweight and dietary saturated fat intake exceeded both the national average (11%) and US Dietary Guidelines (<10%). 14.3% of the cohort fulfilled criteria for MetS with large waist circumference and reduced HDL levels prominently accounting for this status. We evaluated the prevalence of MetS in a cohort of adults living with SCD. Our findings suggest that increased attention to eating habits and physical activity may generate new approaches for decreasing cardiovascular morbidity in SCD.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalBlood Cells, Molecules, and Diseases
Volume74
DOIs
StatePublished - Feb 2019

Keywords

  • Metabolic syndrome
  • Obesity
  • Sickle cell disease

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Hematology
  • Cell Biology

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