Metabolic response of normal human myocardium to high-dose atropine- dobutamine stress studied by 31P-MRS

Hildo J. Lamb, Hugo P. Beyerbacht, Ronald Ouwerkerk, Joost Doornbos, Babette M. Pluim, Ernst E. Van Der Wall, Arnoud D. Van Der Laarse, Albert De Roos

Research output: Contribution to journalArticle

Abstract

Background: 31P-MRS during cardiac stress may provide (patho)physiological insights into the high-energy phosphate metabolism of the myocardium. Accordingly, the purpose of the present study was to determine the metabolic response of normal human myocardium to severe atropine-dobutamine (A-D) stress. To corroborate the results from the present in vivo study, a 31P-MRS experiment was performed with a moving phantom to simulate respiratory motion. Methods and Results: The phantom experiment showed no relation (P=.371) between the intensity ratio of two separate phosphate peaks and amplitude of phantom excursions. The phosphocreatine (PCr) and ATP signal strength and the PCr/ATP ratio were determined from the left ventricular wall in 20 healthy subjects (posttest likelihood for coronary artery disease was 31P-MRS at rest and during high- dose A-D stress (rate-pressure product increased threefold). Stress-induced changes were -21% for PCr (P

Original languageEnglish (US)
Pages (from-to)2969-2977
Number of pages9
JournalCirculation
Volume96
Issue number9
StatePublished - Nov 4 1997
Externally publishedYes

Fingerprint

Dobutamine
Phosphocreatine
Atropine
Myocardium
Adenosine Triphosphate
Phosphates
Energy Metabolism
Coronary Artery Disease
Healthy Volunteers
Pressure

Keywords

  • Inotropic agents
  • Metabolism
  • Phosphates
  • Spectroscopy
  • Stress

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Lamb, H. J., Beyerbacht, H. P., Ouwerkerk, R., Doornbos, J., Pluim, B. M., Van Der Wall, E. E., ... De Roos, A. (1997). Metabolic response of normal human myocardium to high-dose atropine- dobutamine stress studied by 31P-MRS. Circulation, 96(9), 2969-2977.

Metabolic response of normal human myocardium to high-dose atropine- dobutamine stress studied by 31P-MRS. / Lamb, Hildo J.; Beyerbacht, Hugo P.; Ouwerkerk, Ronald; Doornbos, Joost; Pluim, Babette M.; Van Der Wall, Ernst E.; Van Der Laarse, Arnoud D.; De Roos, Albert.

In: Circulation, Vol. 96, No. 9, 04.11.1997, p. 2969-2977.

Research output: Contribution to journalArticle

Lamb, HJ, Beyerbacht, HP, Ouwerkerk, R, Doornbos, J, Pluim, BM, Van Der Wall, EE, Van Der Laarse, AD & De Roos, A 1997, 'Metabolic response of normal human myocardium to high-dose atropine- dobutamine stress studied by 31P-MRS', Circulation, vol. 96, no. 9, pp. 2969-2977.
Lamb HJ, Beyerbacht HP, Ouwerkerk R, Doornbos J, Pluim BM, Van Der Wall EE et al. Metabolic response of normal human myocardium to high-dose atropine- dobutamine stress studied by 31P-MRS. Circulation. 1997 Nov 4;96(9):2969-2977.
Lamb, Hildo J. ; Beyerbacht, Hugo P. ; Ouwerkerk, Ronald ; Doornbos, Joost ; Pluim, Babette M. ; Van Der Wall, Ernst E. ; Van Der Laarse, Arnoud D. ; De Roos, Albert. / Metabolic response of normal human myocardium to high-dose atropine- dobutamine stress studied by 31P-MRS. In: Circulation. 1997 ; Vol. 96, No. 9. pp. 2969-2977.
@article{68462a4b502842c8954cdd9de7013ba0,
title = "Metabolic response of normal human myocardium to high-dose atropine- dobutamine stress studied by 31P-MRS",
abstract = "Background: 31P-MRS during cardiac stress may provide (patho)physiological insights into the high-energy phosphate metabolism of the myocardium. Accordingly, the purpose of the present study was to determine the metabolic response of normal human myocardium to severe atropine-dobutamine (A-D) stress. To corroborate the results from the present in vivo study, a 31P-MRS experiment was performed with a moving phantom to simulate respiratory motion. Methods and Results: The phantom experiment showed no relation (P=.371) between the intensity ratio of two separate phosphate peaks and amplitude of phantom excursions. The phosphocreatine (PCr) and ATP signal strength and the PCr/ATP ratio were determined from the left ventricular wall in 20 healthy subjects (posttest likelihood for coronary artery disease was 31P-MRS at rest and during high- dose A-D stress (rate-pressure product increased threefold). Stress-induced changes were -21{\%} for PCr (P",
keywords = "Inotropic agents, Metabolism, Phosphates, Spectroscopy, Stress",
author = "Lamb, {Hildo J.} and Beyerbacht, {Hugo P.} and Ronald Ouwerkerk and Joost Doornbos and Pluim, {Babette M.} and {Van Der Wall}, {Ernst E.} and {Van Der Laarse}, {Arnoud D.} and {De Roos}, Albert",
year = "1997",
month = "11",
day = "4",
language = "English (US)",
volume = "96",
pages = "2969--2977",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Metabolic response of normal human myocardium to high-dose atropine- dobutamine stress studied by 31P-MRS

AU - Lamb, Hildo J.

AU - Beyerbacht, Hugo P.

AU - Ouwerkerk, Ronald

AU - Doornbos, Joost

AU - Pluim, Babette M.

AU - Van Der Wall, Ernst E.

AU - Van Der Laarse, Arnoud D.

AU - De Roos, Albert

PY - 1997/11/4

Y1 - 1997/11/4

N2 - Background: 31P-MRS during cardiac stress may provide (patho)physiological insights into the high-energy phosphate metabolism of the myocardium. Accordingly, the purpose of the present study was to determine the metabolic response of normal human myocardium to severe atropine-dobutamine (A-D) stress. To corroborate the results from the present in vivo study, a 31P-MRS experiment was performed with a moving phantom to simulate respiratory motion. Methods and Results: The phantom experiment showed no relation (P=.371) between the intensity ratio of two separate phosphate peaks and amplitude of phantom excursions. The phosphocreatine (PCr) and ATP signal strength and the PCr/ATP ratio were determined from the left ventricular wall in 20 healthy subjects (posttest likelihood for coronary artery disease was 31P-MRS at rest and during high- dose A-D stress (rate-pressure product increased threefold). Stress-induced changes were -21% for PCr (P

AB - Background: 31P-MRS during cardiac stress may provide (patho)physiological insights into the high-energy phosphate metabolism of the myocardium. Accordingly, the purpose of the present study was to determine the metabolic response of normal human myocardium to severe atropine-dobutamine (A-D) stress. To corroborate the results from the present in vivo study, a 31P-MRS experiment was performed with a moving phantom to simulate respiratory motion. Methods and Results: The phantom experiment showed no relation (P=.371) between the intensity ratio of two separate phosphate peaks and amplitude of phantom excursions. The phosphocreatine (PCr) and ATP signal strength and the PCr/ATP ratio were determined from the left ventricular wall in 20 healthy subjects (posttest likelihood for coronary artery disease was 31P-MRS at rest and during high- dose A-D stress (rate-pressure product increased threefold). Stress-induced changes were -21% for PCr (P

KW - Inotropic agents

KW - Metabolism

KW - Phosphates

KW - Spectroscopy

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=0030667631&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030667631&partnerID=8YFLogxK

M3 - Article

C2 - 9386164

AN - SCOPUS:0030667631

VL - 96

SP - 2969

EP - 2977

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 9

ER -