Metabolic response of normal human myocardium to high-dose atropine- dobutamine stress studied by 31P-MRS

Hildo J. Lamb, Hugo P. Beyerbacht, Ronald Ouwerkerk, Joost Doornbos, Babette M. Pluim, Ernst E. Van Der Wall, Arnoud D. Van Der Laarse, Albert De Roos

Research output: Contribution to journalArticlepeer-review

Abstract

Background: 31P-MRS during cardiac stress may provide (patho)physiological insights into the high-energy phosphate metabolism of the myocardium. Accordingly, the purpose of the present study was to determine the metabolic response of normal human myocardium to severe atropine-dobutamine (A-D) stress. To corroborate the results from the present in vivo study, a 31P-MRS experiment was performed with a moving phantom to simulate respiratory motion. Methods and Results: The phantom experiment showed no relation (P=.371) between the intensity ratio of two separate phosphate peaks and amplitude of phantom excursions. The phosphocreatine (PCr) and ATP signal strength and the PCr/ATP ratio were determined from the left ventricular wall in 20 healthy subjects (posttest likelihood for coronary artery disease was 31P-MRS at rest and during high- dose A-D stress (rate-pressure product increased threefold). Stress-induced changes were -21% for PCr (P

Original languageEnglish (US)
Pages (from-to)2969-2977
Number of pages9
JournalCirculation
Volume96
Issue number9
StatePublished - Nov 4 1997
Externally publishedYes

Keywords

  • Inotropic agents
  • Metabolism
  • Phosphates
  • Spectroscopy
  • Stress

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Metabolic response of normal human myocardium to high-dose atropine- dobutamine stress studied by 31P-MRS'. Together they form a unique fingerprint.

Cite this