Metabolic Relationship Between Cancer-Associated Fibroblasts and Cancer Cells

Christos Sazeides, Anne Le

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME), play an important role in cancer initiation, progression, and metastasis. Recent findings have demonstrated that the TME not only provides physical support for cancer cells but also directs cell-to-cell interactions (in this case, the interaction between cancer cells and CAFs). As cancer progresses, the CAFs also coevolve, transitioning from an inactivated state to an activated state. The elucidation and understanding of the interaction between cancer cells and CAFs will pave the way for new cancer therapies [1–3].

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages189-204
Number of pages16
DOIs
StatePublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1311
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Alanine
  • CAF-derived exosomes
  • Cancer-associated fibroblasts
  • Cav-1
  • Glutamine metabolism
  • Hypoxia-inducible factor-1
  • Reverse Warburg effect
  • TGF-β
  • miRNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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