Metabolic relationship between cancer-associated fibroblasts and cancer cells

Christos Sazeides, Anne Le

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer-associated fibroblasts undergo the reverse Warburg effect and provide cancer cells with glycolytic metabolites.The interaction between cancer cells and CAFs helps cancer cells manage the Warburg effect.Loss of stromal Cav-1 is a biomarker of poor prognosis in breast cancers.CAF-derived exosomes (CDE) can reprogram the metabolic pathway of cancer cells.CAFs augment cancer addiction to glutamine and its metabolically-relevant consequences.Alanine secreted by pancreatic stellate cells supports tumor metabolism.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages149-165
Number of pages17
DOIs
StatePublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1063
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • CAF-derived exosomes
  • Cancer-associated fibroblasts
  • Glutamine metabolism
  • Hypoxia-inducible factor-1
  • Reverse Warburg effect

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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