Metabolic regulation of T cell immunity

Paolo D.A. Vignali, Joseph Barbi, Fan Pan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

It is becoming increasingly clear that cellular metabolism plays a critical role in the propagation of appropriate, effective, and pathologic immune responses. In this chapter, we detail the metabolic pathways involved in T cell activation and differentiation, highlighting specific factors responsible for directing the processes that lead to metabolic programming at important stages in the dynamic life cycle of this immune cell lineage. Additionally, this chapter will discuss how key metabolites are acquired, touching on the factors and conditions regulating the expression of crucial transporter molecules in response to activation and pathological states.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages87-130
Number of pages44
Volume1011
DOIs
StatePublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1011
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Activation
  • AMPK
  • Differentiation
  • HIF-1
  • Metabolism
  • mTOR
  • Myc
  • Pathways
  • PPAR
  • Regulation
  • T cell

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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