Abstract
Upon encountering pathogens, T cells mount immune responses by proliferating, increasing cellular mass and differentiating. These cellular changes impose significant energetic challenges on T cells. It was believed that TCR and cytokine-mediated signaling are dominant dictators of T cell-mediated immune responses. Recently, it was recognized that T cells utilize metabolic transporters and metabolic sensors that allow them to rapidly respond to nutrient-limiting inflammatory environments. Metabolic sensors allow T cells to find a balance between energy consumption (anabolic metabolism) and production (catabolic metabolism) in order to mount effective immune responses. Also, metabolic regulators interact with cytokine-dependent transcriptional regulators, suggesting a more integrative and advanced model of T cell activation and differentiation. In this review, we will discuss recent discoveries regarding the roles of metabolic regulators in effector and memory T cell development and their interaction with canonical transcription factors.
Original language | English (US) |
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Pages (from-to) | 497-506 |
Number of pages | 10 |
Journal | Molecular Immunology |
Volume | 68 |
Issue number | 2 |
DOIs | |
State | Published - Dec 1 2015 |
Keywords
- Aerobic glycolysis
- Anabolic metabolism
- Catabolic metabolism
- Differentiation
- Effector and memory T cells
- Fatty acid oxidation
- Proliferation
- TCA cycle
- Treg
ASJC Scopus subject areas
- Immunology
- Molecular Biology