Metabolic network reconstruction and genome-scale model of butanol-producing strain clostridium Beijerinckii NCIMB 8052

Caroline B. Milne, Nathan D. Price

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In silico modeling of genome-scale networks offers a promising method for globally interrogating the metabolism of Clostridium beijerinckii, a microorganism of industrial interest for butanol production. The iCM926 model accurately simulates physiological behavior and provides insight into the underlying mechanisms of microbial butanol production. The model will be instrumental in efforts to better understand, and metabolically engineer, this microorganism for improved butanol production. The construction of iCM926 for a lesser-characterized microorganism highlighted important areas of investigation, e.g., genome annotations and objective functions, for future model-building efforts. This is an abstract of a paper presented at the 2011 AIChE Annual Meeting (Minneapolis, MN 10/16-21/2011).

Original languageEnglish (US)
Title of host publication11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings
StatePublished - 2011
Externally publishedYes
Event2011 AIChE Annual Meeting, 11AIChE - Minneapolis, MN, United States
Duration: Oct 16 2011Oct 21 2011

Publication series

Name11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings

Conference

Conference2011 AIChE Annual Meeting, 11AIChE
CountryUnited States
CityMinneapolis, MN
Period10/16/1110/21/11

ASJC Scopus subject areas

  • Chemical Engineering(all)

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