Metabolic imaging of myocardial triglyceride content: Reproducibility of 1H MR spectroscopy with respiratory navigator gating in volunteers

Rutger W. Van Der Meer, Joost Doornbos, Sebastian Kozerke, Michael Schär, Jeroen J. Bax, Sebastiaan Hammer, Johannes W.A. Smit, Johannes A. Romijn, Michaela Diamant, Luuk J. Rijzewijk, Albert De Roos, Hildo J. Lamb

Research output: Contribution to journalArticlepeer-review

Abstract

Institutional review board approval and informed consent were obtained. The purpose of the study was to prospectively compare spectral resolution and reproducibility of hydrogen 1 (1H) magnetic resonance (MR) spectroscopy, with and without respiratory motion compensation based on navigator echoes, in the assessment of myocardial triglyceride content in the human heart. In 20 volunteers (14 men, six women; mean age ± standard error, 31 years ± 2.8 [range, 19-60 years]; body mass index, 19-30 kg/m2) without history of cardiovascular disease, 1H MR spectroscopy of the myocardium was performed at rest, with and without respiratory motion compensation. Unsuppressed water signal linewidth changed from 11.9 Hz to 10.7 Hz (P < .001) with the use of the navigator, which indicated better spectral resolution. The navigator improved the intraclass correlation coefficient for the assessment of myocardial triglyceride content from 0.32 to 0.81. Therefore, the authors believe that respiratory motion correction is essential for reproducible assessment of myocardial triglycerides.

Original languageEnglish (US)
Pages (from-to)251-257
Number of pages7
JournalRADIOLOGY
Volume245
Issue number1
DOIs
StatePublished - Oct 1 2007

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Metabolic imaging of myocardial triglyceride content: Reproducibility of <sup>1</sup>H MR spectroscopy with respiratory navigator gating in volunteers'. Together they form a unique fingerprint.

Cite this