Metabolic effects of sodium nitroprusside on the pig kidney In vivo: Studies by phosphorus-31 magnetic resonance spectroscopy

F. Parivar, P. B. Barker, L. W. Jones, B. D. Ross

Research output: Contribution to journalArticlepeer-review

Abstract

Phosphorus-31 magnetic resonance spectroscopy was applied to the pig kidney in vivo to determine the metabolic effects of infusion of sodium nitroprusside, and of more severe hypotension produced by venesection or halothane. Sodium nitroprusside 7-20 μg kg-1 min-1 reduced mean systemic arterial pressure (AP) of the pig from 89 to 46 mm Hg. Glomerular filtration rate and total sodium reabsorption were reduced proportionally. Renal metabolism, assessed by the ratio [ATP]: [Pi] (inorganic phosphate), did not change. Adding halothane or venesection to nitroprusside hypotension caused a further reduction in systemic AP to 42 and 39 mm Hg, respectively. Renal [ATP] decreased in direct proportion to mean AP. It is concluded that sodium nitroprusside, even in high doses, does not reduce renal oxygen delivery as assessed by the ability of the kidney to maintain normal ATP content. However, haemorrhage or an increase in halothane dosage results in irreversible damage to the energy producing processes of the kidney. This may be relevant to the clinical use of the drug.

Original languageEnglish (US)
Pages (from-to)710-716
Number of pages7
JournalBritish journal of anaesthesia
Volume64
Issue number6
DOIs
StatePublished - Jun 1990
Externally publishedYes

Keywords

  • Anaesthetic techniques: hypotension
  • Complications: renal, adenosine triphosphate
  • Measurement techniques: magnetic resonance spectroscopy
  • Pharmacology: sodium nitroprusside

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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