Metabolic effect of topical application of metrizamide to rat brain cortex

Lars Bech, Nils Henrik Diemer, Albert Gjedde

Research output: Contribution to journalArticlepeer-review

Abstract

ABSTRACT – The x‐ray contrast material metrizamide is structurally related to 2‐deoxyglucose and inhibits brain glucose phosphorylation both in vitro and in vivo. in vivo. In vivo, however, the present autoradiographic study with labeled 2‐deoxyglucose revealed a local increase of glucose metabolic rate in an area of direct metrizamide application to the cerebral cortex. The local increase was 137% above the metabolic rate calculated for the contralateral region. Regions outside the application site showed no difference between the glucose metabolic rates of the ipsi‐and contralateral hemispheres. Evidence from the literature suggests that metrizamide may stimulate cortical activity by inhibiting acetylcholinesterase.

Original languageEnglish (US)
Pages (from-to)427-431
Number of pages5
JournalActa Neurologica Scandinavica
Volume72
Issue number4
DOIs
StatePublished - Oct 1985

Keywords

  • Cerebral glycose metabolism
  • deoxyglucose
  • metrizamide

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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