Metabolic control of the Treg/Th17 axis

Research output: Contribution to journalArticle

Abstract

The interplay of the immune system with other aspects of physiology is continually being revealed and in some cases studied in considerable mechanistic detail. A prime example is the influence of metabolic cues on immune responses. It is well appreciated that upon activation, T cells take on a metabolic profile profoundly distinct from that of their quiescent and anergic counterparts; however, a number of recent breakthroughs have greatly expanded our knowledge of how aspects of cellular metabolism can shape a T-cell response. Particularly important are findings that certain environmental cues can tilt the delicate balance between inflammation and immune tolerance by skewing T-cell fate decisions toward either the T-helper 17 (Th17) or T-regulatory (Treg) cell lineage. Recognizing the unappreciated immune-modifying potential of metabolic factors and particularly those involved in the generation of these functionally opposing T-cell subsets will likely add new and potent therapies to our repertoire for treating immune mediated pathologies. In this review, we summarize and discuss recent findings linking certain metabolic pathways, enzymes, and by-products to shifts in the balance between Th17 and Treg cell populations. These advances highlight numerous opportunities for immune modulation.

Original languageEnglish (US)
Pages (from-to)52-77
Number of pages26
JournalImmunological Reviews
Volume252
Issue number1
DOIs
StatePublished - Mar 2013

Fingerprint

T-Lymphocytes
Cues
Th17 Cells
Immune Tolerance
Metabolome
T-Lymphocyte Subsets
Cell Lineage
Regulatory T-Lymphocytes
Metabolic Networks and Pathways
Immune System
Pathology
Inflammation
Enzymes
Population
Therapeutics

Keywords

  • Metabolism
  • T-cell differentiation
  • Th17
  • Treg

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Metabolic control of the Treg/Th17 axis. / Barbi, Joseph; Pardoll, Andrew Mark; Pan, Fan.

In: Immunological Reviews, Vol. 252, No. 1, 03.2013, p. 52-77.

Research output: Contribution to journalArticle

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