Metabolic control analysis applied to mitochondrial networks

Sonia Cortassa, Miguel A. Aon, Brian O'Rourke, Raimond Winslow

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

To understand the control and regulation of mitochondrial energy metabolism a generalized matrix method of Metabolic Control Analysis has been applied to a computational model of mitochondrial energetics. The computational model of Cortassa et al. (2003) encompasses oxidative phosphorylation, the tricarboxylic acid (TCA) cycle, and ion dynamics across the inner mitochondrial membrane. Control of respiration and ATP synthesis fluxes were found to be distributed among various mitochondrial processes. Control is shared by processes associated with ATP synthesis and ATP/ADP transport, as well as by Ca 2 dynamics. The analysis of flux control coefficients and response coefficients has led to the notion of control by diffuse loops, that points to the regulatory interactions exerted by processes that are mechanistically only indirectly related with each other. The approach we have utilized demonstrates how properties of integrated systems may be understood through applications of computational modeling and control analysis.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Pages4673-4676
Number of pages4
DOIs
StatePublished - 2011
Event33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States
Duration: Aug 30 2011Sep 3 2011

Other

Other33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
CountryUnited States
CityBoston, MA
Period8/30/119/3/11

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Adenosine Triphosphate
Adenosinetriphosphate
Citric Acid Cycle
Oxidative Phosphorylation
Mitochondrial Membranes
Adenosine Diphosphate
Energy Metabolism
Respiration
Ions
Fluxes
Administrative data processing
Membranes

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Cortassa, S., Aon, M. A., O'Rourke, B., & Winslow, R. (2011). Metabolic control analysis applied to mitochondrial networks. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (pp. 4673-4676). [6091157] https://doi.org/10.1109/IEMBS.2011.6091157

Metabolic control analysis applied to mitochondrial networks. / Cortassa, Sonia; Aon, Miguel A.; O'Rourke, Brian; Winslow, Raimond.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2011. p. 4673-4676 6091157.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cortassa, S, Aon, MA, O'Rourke, B & Winslow, R 2011, Metabolic control analysis applied to mitochondrial networks. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS., 6091157, pp. 4673-4676, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011, Boston, MA, United States, 8/30/11. https://doi.org/10.1109/IEMBS.2011.6091157
Cortassa S, Aon MA, O'Rourke B, Winslow R. Metabolic control analysis applied to mitochondrial networks. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2011. p. 4673-4676. 6091157 https://doi.org/10.1109/IEMBS.2011.6091157
Cortassa, Sonia ; Aon, Miguel A. ; O'Rourke, Brian ; Winslow, Raimond. / Metabolic control analysis applied to mitochondrial networks. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2011. pp. 4673-4676
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