Abstract
Four normal adult males and a 7 year old boy with virilizing adrenocortical tumor received an intravenous injection of 7-3H-testosterone sulfate. Twenty-eight to 61% of the tritium injected was recovered in urine collected during the 14 days following the injection with 2.7-11.3% as TS and about 0.0015% as testosterone glucuronide. The disappearance curve of 3H-TS from plasma was found to be represented by three exponentials during the 10-18 hours of study. The metabolic clearance rates ranged from 50 to 89 liters/M2/24 hours in the normal males and was 203 liters/M2/24 hours in the patient with virilizing adrenal tumor. Urinary productions and blood production of TS were similar ranging from 64 to 310 μg/24 hours in normal males, and a value of 2,030 in the patient with virilizing adrenal tumor. Using various assumptions, it was speculated that about 1% of plasma T is converted to plasma TS, while about 0.15% of plasma TS is converted to plasma T.
Original language | English (US) |
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Pages (from-to) | 435-452 |
Number of pages | 18 |
Journal | Steroids |
Volume | 17 |
Issue number | 1-5 |
DOIs | |
State | Published - 1971 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Endocrinology
- Pharmacology
- Clinical Biochemistry
- Organic Chemistry