TY - JOUR
T1 - Metabolic changes after polytrauma
T2 - An imperative for early nutritional support
AU - Hasenboehler, Erik
AU - Williams, Allison
AU - Leinhase, Iris
AU - Morgan, Steven J.
AU - Smith, Wade R.
AU - Moore, Ernest E.
AU - Stahel, Philip F.
PY - 2006
Y1 - 2006
N2 - Major trauma induces marked metabolic changes which contribute to the systemic immune suppression in severely injured patients and increase the risk of infection and posttraumatic organ failure. The hypercatabolic state of polytrauma patients must be recognized early and treated by an appropriate nutritional management in order to avoid late complications. Clinical studies in recent years have supported the concept of "immunonutrition" for severely injured patients, which takes into account the supplementation of Ω-3 fatty acids and essential aminoacids, such as glutamine. Yet many aspects of the nutritional strategies for polytrauma patients remain controversial, including the exact timing, caloric and protein amount of nutrition, choice of enteral versus parenteral route, and duration. The present review will provide an outline of the pathophysiological metabolic changes after major trauma that endorse the current basis for early immunonutrition of polytrauma patients.
AB - Major trauma induces marked metabolic changes which contribute to the systemic immune suppression in severely injured patients and increase the risk of infection and posttraumatic organ failure. The hypercatabolic state of polytrauma patients must be recognized early and treated by an appropriate nutritional management in order to avoid late complications. Clinical studies in recent years have supported the concept of "immunonutrition" for severely injured patients, which takes into account the supplementation of Ω-3 fatty acids and essential aminoacids, such as glutamine. Yet many aspects of the nutritional strategies for polytrauma patients remain controversial, including the exact timing, caloric and protein amount of nutrition, choice of enteral versus parenteral route, and duration. The present review will provide an outline of the pathophysiological metabolic changes after major trauma that endorse the current basis for early immunonutrition of polytrauma patients.
UR - http://www.scopus.com/inward/record.url?scp=33947416884&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33947416884&partnerID=8YFLogxK
U2 - 10.1186/1749-7922-1-29
DO - 10.1186/1749-7922-1-29
M3 - Review article
AN - SCOPUS:33947416884
SN - 1749-7922
VL - 1
JO - World Journal of Emergency Surgery
JF - World Journal of Emergency Surgery
IS - 1
M1 - 29
ER -