Metabolic and Mechanical Cues Regulating Pluripotent Stem Cell Fate

Tânia Perestrelo, Marcelo Correia, João Ramalho-Santos, Denis Wirtz

Research output: Contribution to journalReview articlepeer-review

Abstract

The ability to shift between metabolic states and to tightly regulate cellular mechanical properties have been described as crucial events in the achievement of correct embryonic development. Indeed, metabolic and mechanical manipulations in vitro have led to the discovery of new methods to control cell fate. As these two modulators are usually studied separately, in this review article, we describe how cellular mechanics and metabolic characteristics regulate embryonic development in vivo and describe the role of these cues in the regulation of pluripotency and differentiation in vitro. We also pinpoint possible connections between metabolism and mechanotransduction, highlighting recent findings in the Yes-associated protein, phosphoinositide 3-kinase, and AMP-activated protein kinase signaling pathways, and how they may be relevant in modulating cell fate in other contexts.

Original languageEnglish (US)
Pages (from-to)1014-1029
Number of pages16
JournalTrends in Cell Biology
Volume28
Issue number12
DOIs
StatePublished - Dec 2018

Keywords

  • Development
  • Mechanotransduction
  • Metabolism
  • Pluripotency
  • Stem cells

ASJC Scopus subject areas

  • Cell Biology

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