TY - JOUR
T1 - Metabolic and immune effects of arginine in postinjury hyperalimentation
AU - Barbul, Adrian
AU - Sisto, Donato A.
AU - Wasserkrug, Hannah L.
AU - Yoshimura, Norman N.
AU - Efron, Gershon
PY - 1981/11
Y1 - 1981/11
N2 - Nitrogen balance and thymic immune function studies were carried out in rats subjected to anesthesia, jugular vein catheterization, and bilateral femoral fractures, who were then given for 5 days: A) D5W; B) D20 FreAmine II (total arginine 1.55 gm/L); or C) D20 FreAmine III (4.05 gm of arginine/L). Administration of hypercaloric amino acid mixtures had strong positive effects on nitrogen retention and thymic function when compared to isotonic dextrose infusion. The administration of solution C had the most positive effect on nitrogen balance and on thymic immune function. The data suggest that increased arginine administration may prove beneficial to injured patients.
AB - Nitrogen balance and thymic immune function studies were carried out in rats subjected to anesthesia, jugular vein catheterization, and bilateral femoral fractures, who were then given for 5 days: A) D5W; B) D20 FreAmine II (total arginine 1.55 gm/L); or C) D20 FreAmine III (4.05 gm of arginine/L). Administration of hypercaloric amino acid mixtures had strong positive effects on nitrogen retention and thymic function when compared to isotonic dextrose infusion. The administration of solution C had the most positive effect on nitrogen balance and on thymic immune function. The data suggest that increased arginine administration may prove beneficial to injured patients.
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U2 - 10.1097/00005373-198111000-00011
DO - 10.1097/00005373-198111000-00011
M3 - Article
C2 - 6795362
AN - SCOPUS:0019868660
SN - 0022-5282
VL - 21
SP - 970
EP - 974
JO - Journal of Trauma - Injury, Infection and Critical Care
JF - Journal of Trauma - Injury, Infection and Critical Care
IS - 11
ER -