Metabolic and immune effects of arginine in postinjury hyperalimentation

Adrian Barbul, Donato A. Sisto, Hannah L. Wasserkrug, Norman N. Yoshimura, Gershon Efron

Research output: Contribution to journalArticlepeer-review

Abstract

Nitrogen balance and thymic immune function studies were carried out in rats subjected to anesthesia, jugular vein catheterization, and bilateral femoral fractures, who were then given for 5 days: A) D5W; B) D20 FreAmine II (total arginine 1.55 gm/L); or C) D20 FreAmine III (4.05 gm of arginine/L). Administration of hypercaloric amino acid mixtures had strong positive effects on nitrogen retention and thymic function when compared to isotonic dextrose infusion. The administration of solution C had the most positive effect on nitrogen balance and on thymic immune function. The data suggest that increased arginine administration may prove beneficial to injured patients.

Original languageEnglish (US)
Pages (from-to)970-974
Number of pages5
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume21
Issue number11
DOIs
StatePublished - Nov 1981

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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