Metabolic and immune effects of arginine in postinjury hyperalimentation

Adrian Barbul, Donato A. Sisto, Hannah L. Wasserkrug, Norman N. Yoshimura, Gershon Efron

Research output: Contribution to journalArticle

Abstract

Nitrogen balance and thymic immune function studies were carried out in rats subjected to anesthesia, jugular vein catheterization, and bilateral femoral fractures, who were then given for 5 days: A) D5W; B) D20 FreAmine II (total arginine 1.55 gm/L); or C) D20 FreAmine III (4.05 gm of arginine/L). Administration of hypercaloric amino acid mixtures had strong positive effects on nitrogen retention and thymic function when compared to isotonic dextrose infusion. The administration of solution C had the most positive effect on nitrogen balance and on thymic immune function. The data suggest that increased arginine administration may prove beneficial to injured patients.

Original languageEnglish (US)
Pages (from-to)970-974
Number of pages5
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume21
Issue number11
StatePublished - 1981

Fingerprint

Arginine
Nitrogen
Femoral Fractures
Jugular Veins
Catheterization
Anesthesia
Amino Acids
Glucose
amino-acid, glucose, and electrolyte solution

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Surgery

Cite this

Barbul, A., Sisto, D. A., Wasserkrug, H. L., Yoshimura, N. N., & Efron, G. (1981). Metabolic and immune effects of arginine in postinjury hyperalimentation. Journal of Trauma - Injury, Infection and Critical Care, 21(11), 970-974.

Metabolic and immune effects of arginine in postinjury hyperalimentation. / Barbul, Adrian; Sisto, Donato A.; Wasserkrug, Hannah L.; Yoshimura, Norman N.; Efron, Gershon.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 21, No. 11, 1981, p. 970-974.

Research output: Contribution to journalArticle

Barbul, A, Sisto, DA, Wasserkrug, HL, Yoshimura, NN & Efron, G 1981, 'Metabolic and immune effects of arginine in postinjury hyperalimentation', Journal of Trauma - Injury, Infection and Critical Care, vol. 21, no. 11, pp. 970-974.
Barbul, Adrian ; Sisto, Donato A. ; Wasserkrug, Hannah L. ; Yoshimura, Norman N. ; Efron, Gershon. / Metabolic and immune effects of arginine in postinjury hyperalimentation. In: Journal of Trauma - Injury, Infection and Critical Care. 1981 ; Vol. 21, No. 11. pp. 970-974.
@article{129c420eec7745d29f60cabcea43b8dd,
title = "Metabolic and immune effects of arginine in postinjury hyperalimentation",
abstract = "Nitrogen balance and thymic immune function studies were carried out in rats subjected to anesthesia, jugular vein catheterization, and bilateral femoral fractures, who were then given for 5 days: A) D5W; B) D20 FreAmine II (total arginine 1.55 gm/L); or C) D20 FreAmine III (4.05 gm of arginine/L). Administration of hypercaloric amino acid mixtures had strong positive effects on nitrogen retention and thymic function when compared to isotonic dextrose infusion. The administration of solution C had the most positive effect on nitrogen balance and on thymic immune function. The data suggest that increased arginine administration may prove beneficial to injured patients.",
author = "Adrian Barbul and Sisto, {Donato A.} and Wasserkrug, {Hannah L.} and Yoshimura, {Norman N.} and Gershon Efron",
year = "1981",
language = "English (US)",
volume = "21",
pages = "970--974",
journal = "Journal of Trauma and Acute Care Surgery",
issn = "2163-0755",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Metabolic and immune effects of arginine in postinjury hyperalimentation

AU - Barbul, Adrian

AU - Sisto, Donato A.

AU - Wasserkrug, Hannah L.

AU - Yoshimura, Norman N.

AU - Efron, Gershon

PY - 1981

Y1 - 1981

N2 - Nitrogen balance and thymic immune function studies were carried out in rats subjected to anesthesia, jugular vein catheterization, and bilateral femoral fractures, who were then given for 5 days: A) D5W; B) D20 FreAmine II (total arginine 1.55 gm/L); or C) D20 FreAmine III (4.05 gm of arginine/L). Administration of hypercaloric amino acid mixtures had strong positive effects on nitrogen retention and thymic function when compared to isotonic dextrose infusion. The administration of solution C had the most positive effect on nitrogen balance and on thymic immune function. The data suggest that increased arginine administration may prove beneficial to injured patients.

AB - Nitrogen balance and thymic immune function studies were carried out in rats subjected to anesthesia, jugular vein catheterization, and bilateral femoral fractures, who were then given for 5 days: A) D5W; B) D20 FreAmine II (total arginine 1.55 gm/L); or C) D20 FreAmine III (4.05 gm of arginine/L). Administration of hypercaloric amino acid mixtures had strong positive effects on nitrogen retention and thymic function when compared to isotonic dextrose infusion. The administration of solution C had the most positive effect on nitrogen balance and on thymic immune function. The data suggest that increased arginine administration may prove beneficial to injured patients.

UR - http://www.scopus.com/inward/record.url?scp=0019868660&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019868660&partnerID=8YFLogxK

M3 - Article

C2 - 6795362

AN - SCOPUS:0019868660

VL - 21

SP - 970

EP - 974

JO - Journal of Trauma and Acute Care Surgery

JF - Journal of Trauma and Acute Care Surgery

SN - 2163-0755

IS - 11

ER -