Metabolic actions of adipocyte hormones: focus on adiponectin.

Research output: Contribution to journalReview article

Abstract

The obesity epidemic has focused attention on the endocrine function of adipose tissue. Adipose tissue secretes leptin, cytokines, complement factors, and components of the coagulation cascade, most of which are increased in obesity. In contrast, a strong negative correlation exists between adiponectin and adiposity, insulin sensitivity, diabetes, vascular inflammation, and atherosclerosis. Adiponectin treatment in rodents increases insulin sensitivity and reduces lipids and atherogenesis. Chronic and central adiponectin treatment reduces weight, glucose, and lipids. The insulin-sensitizing action of thiazolidinediones is mediated, in part, through adiponectin. A causal role of adiponectin in diabetes, dyslipidemia, and atherosclerosis has been established in knockout mice. Therefore, adiponectin seems to be a marker of obesity-related diseases and a potential therapeutic target.

Original languageEnglish (US)
JournalObesity
Volume14 Suppl 1
DOIs
StatePublished - Feb 2006
Externally publishedYes

Fingerprint

Adiponectin
Adipocytes
Hormones
Atherosclerosis
Obesity
Insulin Resistance
Adipose Tissue
Lipids
Thiazolidinediones
Blood Coagulation Factors
Adiposity
Dyslipidemias
Leptin
Knockout Mice
Blood Vessels
Rodentia
Insulin
Cytokines
Inflammation
Weights and Measures

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Metabolic actions of adipocyte hormones : focus on adiponectin. / Ahima, Rexford S.

In: Obesity, Vol. 14 Suppl 1, 02.2006.

Research output: Contribution to journalReview article

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