Metabolic abnormalities are common among South American hispanics subjects with normal weight or excess body weight: The CRONICAS cohort study

Catherine P. Benziger, Antonio Bernabé-Ortiz, Robert H Gilman, William Checkley, Liam Smeeth, Germán Málaga, J. Jaime Miranda, Juan P. Casas, George Davey Smith, Shah Ebrahim, Héctor H. García, Luis Huicho, Víctor M. Montori, Gregory B Diette, Fabiola León-Velarde, María Rivera, Robert A Wise

Research output: Contribution to journalArticle

Abstract

Objective: We aimed to characterize metabolic status by body mass index (BMI) status. Methods: The CRONICAS longitudinal study was performed in an age-and-sex stratified random sample of participants aged 35 years or older in four Peruvian settings: Lima (Peru's capital, costal urban, highly urbanized), urban and rural Puno (both high-altitude), and Tumbes (costal semirural). Data from the baseline study, conducted in 2010, was used. Individuals were classified by BMI as normal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2), and obese (≥30 kg/m2), and as metabolically healthy (0-1 metabolic abnormality) or metabolically unhealthy (≥2 abnormalities). Abnormalities included individual components of the metabolic syndrome, high-sensitivity C-reactive protein, and insulin resistance. Results: A total of 3088 (age 55.6±12.6 years, 51.3%females) had all measurements. Of these, 890 (28.8%), 1361 (44.1%) and 837 (27.1%) were normal weight, overweight and obese, respectively. Overall, 19.0%of normal weight in contrast to 54.9%of overweight and 77.7%of obese individuals had ≥3 risk factors (p

Original languageEnglish (US)
Article numbere0138968
JournalPLoS One
Volume10
Issue number11
DOIs
StatePublished - Nov 1 2015

Fingerprint

Hispanic Americans
cohort studies
C-Reactive Protein
Cohort Studies
Body Weight
Insulin
Weights and Measures
body weight
body mass index
Body Mass Index
Peru
C-reactive protein
metabolic syndrome
longitudinal studies
insulin resistance
Longitudinal Studies
Insulin Resistance
risk factors
Economics
gender

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Metabolic abnormalities are common among South American hispanics subjects with normal weight or excess body weight : The CRONICAS cohort study. / Benziger, Catherine P.; Bernabé-Ortiz, Antonio; Gilman, Robert H; Checkley, William; Smeeth, Liam; Málaga, Germán; Miranda, J. Jaime; Casas, Juan P.; Smith, George Davey; Ebrahim, Shah; García, Héctor H.; Huicho, Luis; Montori, Víctor M.; Diette, Gregory B; León-Velarde, Fabiola; Rivera, María; Wise, Robert A.

In: PLoS One, Vol. 10, No. 11, e0138968, 01.11.2015.

Research output: Contribution to journalArticle

Benziger, CP, Bernabé-Ortiz, A, Gilman, RH, Checkley, W, Smeeth, L, Málaga, G, Miranda, JJ, Casas, JP, Smith, GD, Ebrahim, S, García, HH, Huicho, L, Montori, VM, Diette, GB, León-Velarde, F, Rivera, M & Wise, RA 2015, 'Metabolic abnormalities are common among South American hispanics subjects with normal weight or excess body weight: The CRONICAS cohort study', PLoS One, vol. 10, no. 11, e0138968. https://doi.org/10.1371/journal.pone.0138968
Benziger, Catherine P. ; Bernabé-Ortiz, Antonio ; Gilman, Robert H ; Checkley, William ; Smeeth, Liam ; Málaga, Germán ; Miranda, J. Jaime ; Casas, Juan P. ; Smith, George Davey ; Ebrahim, Shah ; García, Héctor H. ; Huicho, Luis ; Montori, Víctor M. ; Diette, Gregory B ; León-Velarde, Fabiola ; Rivera, María ; Wise, Robert A. / Metabolic abnormalities are common among South American hispanics subjects with normal weight or excess body weight : The CRONICAS cohort study. In: PLoS One. 2015 ; Vol. 10, No. 11.
@article{17940cee408b416cbfb0267be25f48f4,
title = "Metabolic abnormalities are common among South American hispanics subjects with normal weight or excess body weight: The CRONICAS cohort study",
abstract = "Objective: We aimed to characterize metabolic status by body mass index (BMI) status. Methods: The CRONICAS longitudinal study was performed in an age-and-sex stratified random sample of participants aged 35 years or older in four Peruvian settings: Lima (Peru's capital, costal urban, highly urbanized), urban and rural Puno (both high-altitude), and Tumbes (costal semirural). Data from the baseline study, conducted in 2010, was used. Individuals were classified by BMI as normal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2), and obese (≥30 kg/m2), and as metabolically healthy (0-1 metabolic abnormality) or metabolically unhealthy (≥2 abnormalities). Abnormalities included individual components of the metabolic syndrome, high-sensitivity C-reactive protein, and insulin resistance. Results: A total of 3088 (age 55.6±12.6 years, 51.3{\%}females) had all measurements. Of these, 890 (28.8{\%}), 1361 (44.1{\%}) and 837 (27.1{\%}) were normal weight, overweight and obese, respectively. Overall, 19.0{\%}of normal weight in contrast to 54.9{\%}of overweight and 77.7{\%}of obese individuals had ≥3 risk factors (p",
author = "Benziger, {Catherine P.} and Antonio Bernab{\'e}-Ortiz and Gilman, {Robert H} and William Checkley and Liam Smeeth and Germ{\'a}n M{\'a}laga and Miranda, {J. Jaime} and Casas, {Juan P.} and Smith, {George Davey} and Shah Ebrahim and Garc{\'i}a, {H{\'e}ctor H.} and Luis Huicho and Montori, {V{\'i}ctor M.} and Diette, {Gregory B} and Fabiola Le{\'o}n-Velarde and Mar{\'i}a Rivera and Wise, {Robert A}",
year = "2015",
month = "11",
day = "1",
doi = "10.1371/journal.pone.0138968",
language = "English (US)",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

TY - JOUR

T1 - Metabolic abnormalities are common among South American hispanics subjects with normal weight or excess body weight

T2 - The CRONICAS cohort study

AU - Benziger, Catherine P.

AU - Bernabé-Ortiz, Antonio

AU - Gilman, Robert H

AU - Checkley, William

AU - Smeeth, Liam

AU - Málaga, Germán

AU - Miranda, J. Jaime

AU - Casas, Juan P.

AU - Smith, George Davey

AU - Ebrahim, Shah

AU - García, Héctor H.

AU - Huicho, Luis

AU - Montori, Víctor M.

AU - Diette, Gregory B

AU - León-Velarde, Fabiola

AU - Rivera, María

AU - Wise, Robert A

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Objective: We aimed to characterize metabolic status by body mass index (BMI) status. Methods: The CRONICAS longitudinal study was performed in an age-and-sex stratified random sample of participants aged 35 years or older in four Peruvian settings: Lima (Peru's capital, costal urban, highly urbanized), urban and rural Puno (both high-altitude), and Tumbes (costal semirural). Data from the baseline study, conducted in 2010, was used. Individuals were classified by BMI as normal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2), and obese (≥30 kg/m2), and as metabolically healthy (0-1 metabolic abnormality) or metabolically unhealthy (≥2 abnormalities). Abnormalities included individual components of the metabolic syndrome, high-sensitivity C-reactive protein, and insulin resistance. Results: A total of 3088 (age 55.6±12.6 years, 51.3%females) had all measurements. Of these, 890 (28.8%), 1361 (44.1%) and 837 (27.1%) were normal weight, overweight and obese, respectively. Overall, 19.0%of normal weight in contrast to 54.9%of overweight and 77.7%of obese individuals had ≥3 risk factors (p

AB - Objective: We aimed to characterize metabolic status by body mass index (BMI) status. Methods: The CRONICAS longitudinal study was performed in an age-and-sex stratified random sample of participants aged 35 years or older in four Peruvian settings: Lima (Peru's capital, costal urban, highly urbanized), urban and rural Puno (both high-altitude), and Tumbes (costal semirural). Data from the baseline study, conducted in 2010, was used. Individuals were classified by BMI as normal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2), and obese (≥30 kg/m2), and as metabolically healthy (0-1 metabolic abnormality) or metabolically unhealthy (≥2 abnormalities). Abnormalities included individual components of the metabolic syndrome, high-sensitivity C-reactive protein, and insulin resistance. Results: A total of 3088 (age 55.6±12.6 years, 51.3%females) had all measurements. Of these, 890 (28.8%), 1361 (44.1%) and 837 (27.1%) were normal weight, overweight and obese, respectively. Overall, 19.0%of normal weight in contrast to 54.9%of overweight and 77.7%of obese individuals had ≥3 risk factors (p

UR - http://www.scopus.com/inward/record.url?scp=84958020007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958020007&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0138968

DO - 10.1371/journal.pone.0138968

M3 - Article

C2 - 26599322

AN - SCOPUS:84958020007

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 11

M1 - e0138968

ER -