Meta-analysis of the acute effects of nicotine and smoking on human performance

Stephen J. Heishman, Bethea A. Kleykamp, Edward G. Singleton

Research output: Contribution to journalArticle

Abstract

Rationale and objective: Empirical studies indicate that nicotine enhances some aspects of attention and cognition, suggesting a role in the maintenance of tobacco dependence. The purpose of this review was to update the literature since our previous review (Heishman et al. Exp Clin Psychopharmacol 2:345-395, 1994) and to determine which aspects of human performance were most sensitive to the effects of nicotine and smoking. Methods We conducted a meta-analysis on the outcome measures of 41 double-blind, placebo-controlled laboratory studies published from 1994 to 2008. In all studies, nicotine was administered, and performance was assessed in healthy adult nonsmokers or smokers who were not tobaccodeprived or minimally deprived (≤2 h). Results There were sufficient effect size data to conduct meta-analyses on nine performance domains, including motor abilities, alerting and orienting attention, and episodic and working memory. We found significant positive effects of nicotine or smoking on six domains: fine motor, alerting attention-accuracy and response time (RT), orienting attention-RT, short-term episodic memoryaccuracy, and working memory-RT (effect size range=0.16 to 0.44). Conclusions The significant effects of nicotine on motor abilities, attention, and memory likely represent true performance enhancement because they are not confounded by withdrawal relief. The beneficial cognitive effects of nicotine have implications for initiation of smoking and maintenance of tobacco dependence.

Original languageEnglish (US)
Pages (from-to)453-469
Number of pages17
JournalPsychopharmacology
Volume210
Issue number4
DOIs
StatePublished - Jul 2010
Externally publishedYes

Fingerprint

Nicotine
Meta-Analysis
Smoking
Short-Term Memory
Reaction Time
Tobacco Use Disorder
Aptitude
Episodic Memory
Maintenance
Cognition
Placebos
Outcome Assessment (Health Care)

Keywords

  • Attention
  • Cognition
  • Memory
  • Motor
  • Nicotine
  • Nonsmokers
  • Performance
  • Smokers
  • Smoking
  • Tobacco

ASJC Scopus subject areas

  • Pharmacology

Cite this

Meta-analysis of the acute effects of nicotine and smoking on human performance. / Heishman, Stephen J.; Kleykamp, Bethea A.; Singleton, Edward G.

In: Psychopharmacology, Vol. 210, No. 4, 07.2010, p. 453-469.

Research output: Contribution to journalArticle

Heishman, Stephen J. ; Kleykamp, Bethea A. ; Singleton, Edward G. / Meta-analysis of the acute effects of nicotine and smoking on human performance. In: Psychopharmacology. 2010 ; Vol. 210, No. 4. pp. 453-469.
@article{b6a51e9a38bc4db6a4820cc5cb7be571,
title = "Meta-analysis of the acute effects of nicotine and smoking on human performance",
abstract = "Rationale and objective: Empirical studies indicate that nicotine enhances some aspects of attention and cognition, suggesting a role in the maintenance of tobacco dependence. The purpose of this review was to update the literature since our previous review (Heishman et al. Exp Clin Psychopharmacol 2:345-395, 1994) and to determine which aspects of human performance were most sensitive to the effects of nicotine and smoking. Methods We conducted a meta-analysis on the outcome measures of 41 double-blind, placebo-controlled laboratory studies published from 1994 to 2008. In all studies, nicotine was administered, and performance was assessed in healthy adult nonsmokers or smokers who were not tobaccodeprived or minimally deprived (≤2 h). Results There were sufficient effect size data to conduct meta-analyses on nine performance domains, including motor abilities, alerting and orienting attention, and episodic and working memory. We found significant positive effects of nicotine or smoking on six domains: fine motor, alerting attention-accuracy and response time (RT), orienting attention-RT, short-term episodic memoryaccuracy, and working memory-RT (effect size range=0.16 to 0.44). Conclusions The significant effects of nicotine on motor abilities, attention, and memory likely represent true performance enhancement because they are not confounded by withdrawal relief. The beneficial cognitive effects of nicotine have implications for initiation of smoking and maintenance of tobacco dependence.",
keywords = "Attention, Cognition, Memory, Motor, Nicotine, Nonsmokers, Performance, Smokers, Smoking, Tobacco",
author = "Heishman, {Stephen J.} and Kleykamp, {Bethea A.} and Singleton, {Edward G.}",
year = "2010",
month = "7",
doi = "10.1007/s00213-010-1848-1",
language = "English (US)",
volume = "210",
pages = "453--469",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Meta-analysis of the acute effects of nicotine and smoking on human performance

AU - Heishman, Stephen J.

AU - Kleykamp, Bethea A.

AU - Singleton, Edward G.

PY - 2010/7

Y1 - 2010/7

N2 - Rationale and objective: Empirical studies indicate that nicotine enhances some aspects of attention and cognition, suggesting a role in the maintenance of tobacco dependence. The purpose of this review was to update the literature since our previous review (Heishman et al. Exp Clin Psychopharmacol 2:345-395, 1994) and to determine which aspects of human performance were most sensitive to the effects of nicotine and smoking. Methods We conducted a meta-analysis on the outcome measures of 41 double-blind, placebo-controlled laboratory studies published from 1994 to 2008. In all studies, nicotine was administered, and performance was assessed in healthy adult nonsmokers or smokers who were not tobaccodeprived or minimally deprived (≤2 h). Results There were sufficient effect size data to conduct meta-analyses on nine performance domains, including motor abilities, alerting and orienting attention, and episodic and working memory. We found significant positive effects of nicotine or smoking on six domains: fine motor, alerting attention-accuracy and response time (RT), orienting attention-RT, short-term episodic memoryaccuracy, and working memory-RT (effect size range=0.16 to 0.44). Conclusions The significant effects of nicotine on motor abilities, attention, and memory likely represent true performance enhancement because they are not confounded by withdrawal relief. The beneficial cognitive effects of nicotine have implications for initiation of smoking and maintenance of tobacco dependence.

AB - Rationale and objective: Empirical studies indicate that nicotine enhances some aspects of attention and cognition, suggesting a role in the maintenance of tobacco dependence. The purpose of this review was to update the literature since our previous review (Heishman et al. Exp Clin Psychopharmacol 2:345-395, 1994) and to determine which aspects of human performance were most sensitive to the effects of nicotine and smoking. Methods We conducted a meta-analysis on the outcome measures of 41 double-blind, placebo-controlled laboratory studies published from 1994 to 2008. In all studies, nicotine was administered, and performance was assessed in healthy adult nonsmokers or smokers who were not tobaccodeprived or minimally deprived (≤2 h). Results There were sufficient effect size data to conduct meta-analyses on nine performance domains, including motor abilities, alerting and orienting attention, and episodic and working memory. We found significant positive effects of nicotine or smoking on six domains: fine motor, alerting attention-accuracy and response time (RT), orienting attention-RT, short-term episodic memoryaccuracy, and working memory-RT (effect size range=0.16 to 0.44). Conclusions The significant effects of nicotine on motor abilities, attention, and memory likely represent true performance enhancement because they are not confounded by withdrawal relief. The beneficial cognitive effects of nicotine have implications for initiation of smoking and maintenance of tobacco dependence.

KW - Attention

KW - Cognition

KW - Memory

KW - Motor

KW - Nicotine

KW - Nonsmokers

KW - Performance

KW - Smokers

KW - Smoking

KW - Tobacco

UR - http://www.scopus.com/inward/record.url?scp=77955663393&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955663393&partnerID=8YFLogxK

U2 - 10.1007/s00213-010-1848-1

DO - 10.1007/s00213-010-1848-1

M3 - Article

C2 - 20414766

AN - SCOPUS:77955663393

VL - 210

SP - 453

EP - 469

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 4

ER -