Meta-analysis of animal fat or animal protein intake and colorectal cancer

Dominik D. Alexander, Colleen A. Cushing, Kimberly A. Lowe, Bonnielin Swenor, Mark A. Roberts

Research output: Contribution to journalArticle

Abstract

Background: In the recent World Cancer Research Fund/American Institute for Cancer Research report of diet and cancer, it was concluded that there is limited but suggestive evidence that animal fat intake increases the risk of colorectal cancer. Objective: To clarify this potential relation, we conducted metaanalyses across a variety of subgroups, incorporating data from additional studies. Design: Analyses of high compared with low animal fat intakes and categorical dose-response evaluations were conducted. Subgroup analyses, consisting of evaluations by study design, sex, and tumor site were also performed. Results: Six prospective cohort studies with comprehensive dietary assessments, contributing 1070 cases of colorectal cancer and ≈1.5 million person-years of follow-up, were identified. The summary relative risk estimate (SRRE) for these studies was 1.04 (95% CI: 0.83, 1.31; P for heterogeneity = 0.221) on the basis of high compared with low intakes. When data from case-control studies were combined with the cohort data, the resulting SRRE was 1.15 (95% CI: 0.93, 1.42) with increased variability (P for heterogeneity = 0.015). In our dose-response analysis of the cohort studies, no association between a 20-g/d increment in animal fat intake and colorectal cancer was observed (SRRE: 1.02; 95% CI: 0.95, 1.09). In a separate analysis of 3 prospective cohort studies that reported data for animal protein or meat protein, no significant association with colorectal cancer was observed (SRRE: 0.90; 95% CI: 0.70, 1.15). Conclusion: On the basis of the results of this quantitative assessment, the available epidemiologic evidence does not appear to support an independent association between animal fat intake or animal protein intake and colorectal cancer.

Original languageEnglish (US)
Pages (from-to)1402-1409
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume89
Issue number5
DOIs
StatePublished - Jan 5 2009
Externally publishedYes

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Meta-Analysis
Colorectal Neoplasms
Fats
Proteins
Cohort Studies
Neoplasms
Prospective Studies
Meat
Case-Control Studies
Diet
Research

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

Meta-analysis of animal fat or animal protein intake and colorectal cancer. / Alexander, Dominik D.; Cushing, Colleen A.; Lowe, Kimberly A.; Swenor, Bonnielin; Roberts, Mark A.

In: American Journal of Clinical Nutrition, Vol. 89, No. 5, 05.01.2009, p. 1402-1409.

Research output: Contribution to journalArticle

Alexander, Dominik D. ; Cushing, Colleen A. ; Lowe, Kimberly A. ; Swenor, Bonnielin ; Roberts, Mark A. / Meta-analysis of animal fat or animal protein intake and colorectal cancer. In: American Journal of Clinical Nutrition. 2009 ; Vol. 89, No. 5. pp. 1402-1409.
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