Meta-analysis: Drawing conclusions when study results vary

Leslie Rosenthal, Enrique Schisterman

Research output: Chapter in Book/Report/Conference proceedingChapter


Low-dose aspirin has been suggested to positively impact a number of clinical outcomes associated with oxidative stress; however, results of clinical trials surrounding its effect on a woman's ability to achieve and sustain pregnancy have been inconclusive. A meta-analysis is an advantageous tool in this situation. Meta-analyses allow researchers to formally and systematically pool together all relevant research in order to clarify findings and form conclusions based on all currently available information. The purpose of this chapter is to describe how to perform a meta-analysis, clarify the impact of model selection, and provide examples of implementation.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages8
ISBN (Print)9781607614104
Publication statusPublished - 2010
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)10643745



  • Fixed-effects model
  • Low dose aspirin
  • Meta-analysis
  • Oxidative stress
  • Random-effects model

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Medicine(all)

Cite this

Rosenthal, L., & Schisterman, E. (2010). Meta-analysis: Drawing conclusions when study results vary. In Methods in Molecular Biology (Vol. 594, pp. 427-434). (Methods in Molecular Biology; Vol. 594). Humana Press Inc..