Meta-analysis and evidence

Steven N. Goodman

Research output: Contribution to journalArticle

Abstract

Meta-analysis is the science of combining evidence from different studies, but traditional statistical techniques contain neither a formal definition nor a measure of evidence. It is argued in this paper that the log-likelihood ratio, as a measure of the "weight of evidence" can be a very useful tool in the meta-analysis. The mathematics and the philosophy behind the use of this index are introduced. The construction and interpretation of "support curves" in fixed and random-effects models are presented. The application of evidential techniques is illustrated on six trials of aspirin therapy previously presented by Canner. The possible dangers of focusing on statistical error rates instead of evidence are discussed.

Original languageEnglish (US)
Pages (from-to)188-204
Number of pages17
JournalControlled Clinical Trials
Volume10
Issue number2
DOIs
StatePublished - 1989

Keywords

  • evidence
  • Inference
  • likelihood
  • meta-analysis
  • p values
  • pooling
  • ratio
  • support curves

ASJC Scopus subject areas

  • Pharmacology

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