Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

Dana B. Hancock, Mark Eijgelsheim, Jemma B. Wilk, Sina A. Gharib, Laura R. Loehr, Kristin D. Marciante, Nora Franceschini, Yannick M T A Van Durme, Ting Hsu Chen, R. Graham Barr, Matthew B. Schabath, David J. Couper, Guy G. Brusselle, Bruce M. Psaty, Cornelia M. Van Duijn, Jerome I. Rotter, André G. Uitterlinden, Albert Hofman, Naresh M Punjabi, Fernando Rivadeneira & 8 others Alanna C. Morrison, Paul L. Enright, Kari E. North, Susan R. Heckbert, Thomas Lumley, Bruno H C Stricker, George T. O'Connor, Stephanie J. London

Research output: Contribution to journalArticle

Abstract

Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV 1) and its ratio to forced vital capacity (FEV1 /FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV 1 /FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV 1 (INTS12-GSTCD-NPNT) at or near genome-wide significance (P 5 × 10-8) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalNature Genetics
Volume42
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Genome-Wide Association Study
Meta-Analysis
Lung
Vital Capacity
Health
Forced Expiratory Volume
Lung Diseases
Atherosclerosis
Chronic Disease
Genome
Morbidity
Mortality

ASJC Scopus subject areas

  • Genetics

Cite this

Hancock, D. B., Eijgelsheim, M., Wilk, J. B., Gharib, S. A., Loehr, L. R., Marciante, K. D., ... London, S. J. (2010). Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nature Genetics, 42(1), 45-52. https://doi.org/10.1038/ng.500

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. / Hancock, Dana B.; Eijgelsheim, Mark; Wilk, Jemma B.; Gharib, Sina A.; Loehr, Laura R.; Marciante, Kristin D.; Franceschini, Nora; Van Durme, Yannick M T A; Chen, Ting Hsu; Barr, R. Graham; Schabath, Matthew B.; Couper, David J.; Brusselle, Guy G.; Psaty, Bruce M.; Van Duijn, Cornelia M.; Rotter, Jerome I.; Uitterlinden, André G.; Hofman, Albert; Punjabi, Naresh M; Rivadeneira, Fernando; Morrison, Alanna C.; Enright, Paul L.; North, Kari E.; Heckbert, Susan R.; Lumley, Thomas; Stricker, Bruno H C; O'Connor, George T.; London, Stephanie J.

In: Nature Genetics, Vol. 42, No. 1, 01.2010, p. 45-52.

Research output: Contribution to journalArticle

Hancock, DB, Eijgelsheim, M, Wilk, JB, Gharib, SA, Loehr, LR, Marciante, KD, Franceschini, N, Van Durme, YMTA, Chen, TH, Barr, RG, Schabath, MB, Couper, DJ, Brusselle, GG, Psaty, BM, Van Duijn, CM, Rotter, JI, Uitterlinden, AG, Hofman, A, Punjabi, NM, Rivadeneira, F, Morrison, AC, Enright, PL, North, KE, Heckbert, SR, Lumley, T, Stricker, BHC, O'Connor, GT & London, SJ 2010, 'Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function', Nature Genetics, vol. 42, no. 1, pp. 45-52. https://doi.org/10.1038/ng.500
Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD et al. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nature Genetics. 2010 Jan;42(1):45-52. https://doi.org/10.1038/ng.500
Hancock, Dana B. ; Eijgelsheim, Mark ; Wilk, Jemma B. ; Gharib, Sina A. ; Loehr, Laura R. ; Marciante, Kristin D. ; Franceschini, Nora ; Van Durme, Yannick M T A ; Chen, Ting Hsu ; Barr, R. Graham ; Schabath, Matthew B. ; Couper, David J. ; Brusselle, Guy G. ; Psaty, Bruce M. ; Van Duijn, Cornelia M. ; Rotter, Jerome I. ; Uitterlinden, André G. ; Hofman, Albert ; Punjabi, Naresh M ; Rivadeneira, Fernando ; Morrison, Alanna C. ; Enright, Paul L. ; North, Kari E. ; Heckbert, Susan R. ; Lumley, Thomas ; Stricker, Bruno H C ; O'Connor, George T. ; London, Stephanie J. / Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. In: Nature Genetics. 2010 ; Vol. 42, No. 1. pp. 45-52.
@article{5b83390f037d45fa8507e737c5f72462,
title = "Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function",
abstract = "Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV 1) and its ratio to forced vital capacity (FEV1 /FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV 1 /FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV 1 (INTS12-GSTCD-NPNT) at or near genome-wide significance (P 5 × 10-8) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.",
author = "Hancock, {Dana B.} and Mark Eijgelsheim and Wilk, {Jemma B.} and Gharib, {Sina A.} and Loehr, {Laura R.} and Marciante, {Kristin D.} and Nora Franceschini and {Van Durme}, {Yannick M T A} and Chen, {Ting Hsu} and Barr, {R. Graham} and Schabath, {Matthew B.} and Couper, {David J.} and Brusselle, {Guy G.} and Psaty, {Bruce M.} and {Van Duijn}, {Cornelia M.} and Rotter, {Jerome I.} and Uitterlinden, {Andr{\'e} G.} and Albert Hofman and Punjabi, {Naresh M} and Fernando Rivadeneira and Morrison, {Alanna C.} and Enright, {Paul L.} and North, {Kari E.} and Heckbert, {Susan R.} and Thomas Lumley and Stricker, {Bruno H C} and O'Connor, {George T.} and London, {Stephanie J.}",
year = "2010",
month = "1",
doi = "10.1038/ng.500",
language = "English (US)",
volume = "42",
pages = "45--52",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

AU - Hancock, Dana B.

AU - Eijgelsheim, Mark

AU - Wilk, Jemma B.

AU - Gharib, Sina A.

AU - Loehr, Laura R.

AU - Marciante, Kristin D.

AU - Franceschini, Nora

AU - Van Durme, Yannick M T A

AU - Chen, Ting Hsu

AU - Barr, R. Graham

AU - Schabath, Matthew B.

AU - Couper, David J.

AU - Brusselle, Guy G.

AU - Psaty, Bruce M.

AU - Van Duijn, Cornelia M.

AU - Rotter, Jerome I.

AU - Uitterlinden, André G.

AU - Hofman, Albert

AU - Punjabi, Naresh M

AU - Rivadeneira, Fernando

AU - Morrison, Alanna C.

AU - Enright, Paul L.

AU - North, Kari E.

AU - Heckbert, Susan R.

AU - Lumley, Thomas

AU - Stricker, Bruno H C

AU - O'Connor, George T.

AU - London, Stephanie J.

PY - 2010/1

Y1 - 2010/1

N2 - Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV 1) and its ratio to forced vital capacity (FEV1 /FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV 1 /FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV 1 (INTS12-GSTCD-NPNT) at or near genome-wide significance (P 5 × 10-8) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.

AB - Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV 1) and its ratio to forced vital capacity (FEV1 /FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV 1 /FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV 1 (INTS12-GSTCD-NPNT) at or near genome-wide significance (P 5 × 10-8) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.

UR - http://www.scopus.com/inward/record.url?scp=73349111257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73349111257&partnerID=8YFLogxK

U2 - 10.1038/ng.500

DO - 10.1038/ng.500

M3 - Article

VL - 42

SP - 45

EP - 52

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 1

ER -