Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

Dana B. Hancock; Mark Eijgelsheim; Jemma B. Wilk; Sina A. Gharib; Laura R. Loehr; Kristin D. Marciante; Nora Franceschini; Yannick M.T.A. Van Durme; Ting Hsu Chen; R. Graham Barr; Matthew B. Schabath; David J. Couper; Guy G. Brusselle; Bruce M. Psaty; Cornelia M. Van Duijn; Jerome I. Rotter; André G. Uitterlinden; Albert Hofman; Naresh M. Punjabi; Fernando Rivadeneira; Alanna C. Morrison; Paul L. Enright; Kari E. North; Susan R. Heckbert; Thomas Lumley; Bruno H.C. Stricker; George T. O'Connor; Stephanie J. London

doi:10.1038/ng.500

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

Dana B. Hancock, Mark Eijgelsheim, Jemma B. Wilk, Sina A. Gharib, Laura R. Loehr, Kristin D. Marciante, Nora Franceschini, Yannick M.T.A. Van Durme, Ting Hsu Chen, R. Graham Barr, Matthew B. Schabath, David J. Couper, Guy G. Brusselle, Bruce M. Psaty, Cornelia M. Van Duijn, Jerome I. Rotter, André G. Uitterlinden, Albert Hofman, Naresh M. Punjabi, Fernando RivadeneiraAlanna C. Morrison, Paul L. Enright, Kari E. North, Susan R. Heckbert, Thomas Lumley, Bruno H.C. Stricker, George T. O'Connor, Stephanie J. London

School of Medicine

Research output: Contribution to journal › Article

Abstract

Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV ₁) and its ratio to forced vital capacity (FEV₁ /FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV 1 /FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV ₁ (INTS12-GSTCD-NPNT) at or near genome-wide significance (P 5 × 10^-8) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.

Original language	English (US)
Pages (from-to)	45-52
Number of pages	8
Journal	Nature genetics
Volume	42
Issue number	1
DOIs	https://doi.org/10.1038/ng.500
State	Published - Jan 1 2010

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Hancock, D. B., Eijgelsheim, M., Wilk, J. B., Gharib, S. A., Loehr, L. R., Marciante, K. D., Franceschini, N., Van Durme, Y. M. T. A., Chen, T. H., Barr, R. G., Schabath, M. B., Couper, D. J., Brusselle, G. G., Psaty, B. M., Van Duijn, C. M., Rotter, J. I., Uitterlinden, A. G., Hofman, A., Punjabi, N. M., ... London, S. J. (2010). Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nature genetics, 42(1), 45-52. https://doi.org/10.1038/ng.500

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. / Hancock, Dana B.; Eijgelsheim, Mark; Wilk, Jemma B.; Gharib, Sina A.; Loehr, Laura R.; Marciante, Kristin D.; Franceschini, Nora; Van Durme, Yannick M.T.A.; Chen, Ting Hsu; Barr, R. Graham; Schabath, Matthew B.; Couper, David J.; Brusselle, Guy G.; Psaty, Bruce M.; Van Duijn, Cornelia M.; Rotter, Jerome I.; Uitterlinden, André G.; Hofman, Albert; Punjabi, Naresh M.; Rivadeneira, Fernando; Morrison, Alanna C.; Enright, Paul L.; North, Kari E.; Heckbert, Susan R.; Lumley, Thomas; Stricker, Bruno H.C.; O'Connor, George T.; London, Stephanie J.

In: Nature genetics, Vol. 42, No. 1, 01.01.2010, p. 45-52.

Research output: Contribution to journal › Article

Hancock, DB, Eijgelsheim, M, Wilk, JB, Gharib, SA, Loehr, LR, Marciante, KD, Franceschini, N, Van Durme, YMTA, Chen, TH, Barr, RG, Schabath, MB, Couper, DJ, Brusselle, GG, Psaty, BM, Van Duijn, CM, Rotter, JI, Uitterlinden, AG, Hofman, A, Punjabi, NM, Rivadeneira, F, Morrison, AC, Enright, PL, North, KE, Heckbert, SR, Lumley, T, Stricker, BHC, O'Connor, GT & London, SJ 2010, 'Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function', Nature genetics, vol. 42, no. 1, pp. 45-52. https://doi.org/10.1038/ng.500

Hancock, Dana B. ; Eijgelsheim, Mark ; Wilk, Jemma B. ; Gharib, Sina A. ; Loehr, Laura R. ; Marciante, Kristin D. ; Franceschini, Nora ; Van Durme, Yannick M.T.A. ; Chen, Ting Hsu ; Barr, R. Graham ; Schabath, Matthew B. ; Couper, David J. ; Brusselle, Guy G. ; Psaty, Bruce M. ; Van Duijn, Cornelia M. ; Rotter, Jerome I. ; Uitterlinden, André G. ; Hofman, Albert ; Punjabi, Naresh M. ; Rivadeneira, Fernando ; Morrison, Alanna C. ; Enright, Paul L. ; North, Kari E. ; Heckbert, Susan R. ; Lumley, Thomas ; Stricker, Bruno H.C. ; O'Connor, George T. ; London, Stephanie J. / Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. In: Nature genetics. 2010 ; Vol. 42, No. 1. pp. 45-52.

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