Mesoporous silica-coated hollow manganese oxide nanoparticles as positive T 1 contrast agents for labeling and MRI tracking of adipose-derived mesenchymal stem cells

Taeho Kim, Eric Momin, Jonghoon Choi, Kristy Yuan, Hasan Zaidi, Jaeyun Kim, Mihyun Park, Nohyun Lee, Michael T. McMahon, Alfredo Quinones-Hinojosa, Jeff W.M. Bulte, Taeghwan Hyeon, Assaf A. Gilad

Research output: Contribution to journalArticle


Mesoporous silica-coated hollow manganese oxide (HMnO@mSiO2) nanoparticles were developed as a novel T1 magnetic resonance imaging (MRI) contrast agent. We hypothesized that the mesoporous structure of the nanoparticle shell enables optimal access of water molecules to the magnetic core, and consequently, an effective longitudinal (R1) relaxation enhancement of water protons, which value was measured to be 0.99 (mM -1s-1) at 11.7 T. Adipose-derived mesenchymal stem cells (MSCs) were efficiently labeled using electroporation, with much shorter T 1 values as compared to direct incubation without electroporation, which was also evidenced by signal enhancement on T1-weighted MR images in vitro. Intracranial grafting of HMnO@mSiO2-labeled MSCs enabled serial MR monitoring of cell transplants over 14 days. These novel nanoparticles may extend the arsenal of currently available nanoparticle MR contrast agents by providing positive contrast on T1-weighted images at high magnetic field strengths.

Original languageEnglish (US)
Pages (from-to)2955-2961
Number of pages7
JournalJournal of the American Chemical Society
Issue number9
StatePublished - Mar 9 2011


ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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