Mesenteric vascular effects of prostaglandins F2α and B2. Possible advantages over vasopressin in control of gastrointestinal bleeding

J. W. Fara, K. H. Barth, R. I. White, T. E. Bynum

Research output: Contribution to journalArticlepeer-review

Abstract

Mesenteric vascular effects of prostaglandin B2 and F2α were studied and compared to those of vasopressin in the dog, cat and baboon. Vasopressin reduced superior mesenteric blood flow (SMBF) 80-100%, and significantly increased hepatic arterial blood flow and systemic arterial pressure. Prostaglandin B2 produced vasodilatation at low doses and biphasic vasodilatation/vasoconstriction at high doses. Prostaglandin F2α elicited only vasoconstriction, reducing SMBF, left gastric, and inferior mesenteric blood flow 80-100%. Systemic arterial pressure was not significantly changed. Thus, vasopressin and prostaglandin F2α are equally effective mesenteric vasoconstrictors. Because of reduced systemic effects, prostaglandin F2α has excellent potential as a mesenteric vasoconstrictor to control gastrointestinal hemorrhage.

Original languageEnglish (US)
Pages (from-to)317-320
Number of pages4
JournalRadiology
Volume133
Issue number2
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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