Mesenteric mast cell degranulation in acute T-2 toxin poisoning

J. A. Doebler, L. J. Martin, J. D. Morse, G. P. Ballough, J. A. Strauss, A. Anthony

Research output: Contribution to journalArticlepeer-review


T-2 toxin-induced alterations in rat mesenteric mast cell granulation were measured by cytophotometric analyses of the metachromatic reaction of mast cell granules with azure B. Hypogranulation (diminution of metachromatic material) was observed 8 h following injections of T-2 toxin (0.5-1.5 LD50,i.p.). These data suggest that mast cell activation occurs during acute T-2 intoxication and raise the possibility that mast cell mediators may contribute to toxin-induced cardiovascular collapse.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalToxicology Letters
Issue number1
StatePublished - Aug 1992
Externally publishedYes


  • Mast cell
  • Metachromasia
  • Rat
  • T-2 Toxin

ASJC Scopus subject areas

  • Toxicology

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