Mesenteric mast cell degranulation in acute T-2 toxin poisoning

J. A. Doebler; L. J. Martin; J. D. Morse; G. P. Ballough; J. A. Strauss; A. Anthony

doi:10.1016/0378-4274(92)90075-U

Mesenteric mast cell degranulation in acute T-2 toxin poisoning

J. A. Doebler, L. J. Martin, J. D. Morse, G. P. Ballough, J. A. Strauss, A. Anthony

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

T-2 toxin-induced alterations in rat mesenteric mast cell granulation were measured by cytophotometric analyses of the metachromatic reaction of mast cell granules with azure B. Hypogranulation (diminution of metachromatic material) was observed 8 h following injections of T-2 toxin (0.5-1.5 LD₅₀,i.p.). These data suggest that mast cell activation occurs during acute T-2 intoxication and raise the possibility that mast cell mediators may contribute to toxin-induced cardiovascular collapse.

Original language	English (US)
Pages (from-to)	33-38
Number of pages	6
Journal	Toxicology Letters
Volume	62
Issue number	1
DOIs	https://doi.org/10.1016/0378-4274(92)90075-U
State	Published - Aug 1992
Externally published	Yes

Keywords

Mast cell
Metachromasia
Rat
T-2 Toxin

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(92)90075-U

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title = "Mesenteric mast cell degranulation in acute T-2 toxin poisoning",

abstract = "T-2 toxin-induced alterations in rat mesenteric mast cell granulation were measured by cytophotometric analyses of the metachromatic reaction of mast cell granules with azure B. Hypogranulation (diminution of metachromatic material) was observed 8 h following injections of T-2 toxin (0.5-1.5 LD50,i.p.). These data suggest that mast cell activation occurs during acute T-2 intoxication and raise the possibility that mast cell mediators may contribute to toxin-induced cardiovascular collapse.",

keywords = "Mast cell, Metachromasia, Rat, T-2 Toxin",

author = "Doebler, {J. A.} and Martin, {L. J.} and Morse, {J. D.} and Ballough, {G. P.} and Strauss, {J. A.} and A. Anthony",

year = "1992",

month = aug,

doi = "10.1016/0378-4274(92)90075-U",

language = "English (US)",

volume = "62",

pages = "33--38",

journal = "Toxicology Letters",

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T1 - Mesenteric mast cell degranulation in acute T-2 toxin poisoning

AU - Doebler, J. A.

AU - Martin, L. J.

AU - Morse, J. D.

AU - Ballough, G. P.

AU - Strauss, J. A.

AU - Anthony, A.

PY - 1992/8

Y1 - 1992/8

N2 - T-2 toxin-induced alterations in rat mesenteric mast cell granulation were measured by cytophotometric analyses of the metachromatic reaction of mast cell granules with azure B. Hypogranulation (diminution of metachromatic material) was observed 8 h following injections of T-2 toxin (0.5-1.5 LD50,i.p.). These data suggest that mast cell activation occurs during acute T-2 intoxication and raise the possibility that mast cell mediators may contribute to toxin-induced cardiovascular collapse.

AB - T-2 toxin-induced alterations in rat mesenteric mast cell granulation were measured by cytophotometric analyses of the metachromatic reaction of mast cell granules with azure B. Hypogranulation (diminution of metachromatic material) was observed 8 h following injections of T-2 toxin (0.5-1.5 LD50,i.p.). These data suggest that mast cell activation occurs during acute T-2 intoxication and raise the possibility that mast cell mediators may contribute to toxin-induced cardiovascular collapse.

KW - Mast cell

KW - Metachromasia

KW - Rat

KW - T-2 Toxin

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DO - 10.1016/0378-4274(92)90075-U

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AN - SCOPUS:0026643646

SN - 0378-4274

VL - 62

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EP - 38

JO - Toxicology Letters

JF - Toxicology Letters

IS - 1

ER -

Mesenteric mast cell degranulation in acute T-2 toxin poisoning

Abstract

Keywords

ASJC Scopus subject areas

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