Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration

Dae Hyun Ha, Hyun Keun Kim, Joon Lee, Hyuck Hoon Kwon, Gyeong Hun Park, Steve Hoseong Yang, Jae Yoon Jung, Hosung Choi, Jun Ho Lee, Sumi Sung, Yong Weon Yi, Byong Seung Cho

Research output: Contribution to journalReview article

Abstract

Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication. With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the characteristics of producer cells, exosomes can be utilized as cell-free therapeutics. Among exosomes derived from various cellular origins, mesenchymal stem cell-derived exosomes (MSC-exosomes) have gained great attention due to their immunomodulatory and regenerative functions. Indeed, many studies have shown anti-inflammatory, anti-aging and wound healing effects of MSC-exosomes in various in vitro and in vivo models. In addition, recent advances in the field of exosome biology have enabled development of specific guidelines and quality control methods, which will ultimately lead to clinical application of exosomes. This review highlights recent studies that investigate therapeutic potential of MSC-exosomes and relevant mode of actions for skin diseases, as well as quality control measures required for development of exosome-derived therapeutics.

Original languageEnglish (US)
JournalCells
Volume9
Issue number5
DOIs
StatePublished - May 7 2020

Keywords

  • anti-aging
  • anti-inflammation
  • hair growth
  • immunomodulation
  • mesenchymal stem cells (MSCs)
  • MSC-exosomes
  • regenerative aesthetics
  • skin barrier
  • therapeutics
  • wound healing

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    Ha, D. H., Kim, H. K., Lee, J., Kwon, H. H., Park, G. H., Yang, S. H., Jung, J. Y., Choi, H., Lee, J. H., Sung, S., Yi, Y. W., & Cho, B. S. (2020). Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration. Cells, 9(5). https://doi.org/10.3390/cells9051157