Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate

W. Nathaniel Brennen, Baohui Zhang, Ibrahim Kulac, L. Nelleke Kisteman, Lizamma Antony, Hao Wang, Alan K. Meeker, Angelo M. De Marzo, Isla P. Garraway, Samuel R. Denmeade, John T. Isaacs

Research output: Contribution to journalArticlepeer-review

Abstract

Mesenchymal Stem Cells (MSCs) have been identified in prostate cancer, raising the critical question of their physical and temporal source. Therefore, MSCs were quantified and characterized in benign and malignant prostate tissue representing different disease states and a wide range of age groups from fetal development through adult death using analytical and functional methodologies. In contrast to lineage-restricted Mesenchymal Progenitor Cells (MPCs) found in normal prostate tissue, MSCs with tri-lineage differentiation potential (adipogenesis, osteogenesis, and chondrogenesis) are identified in prostate tissue from a subset of men with prostate cancer, consistent with an influx of more stem-like progenitors (i.e. MSCs) from the bone marrow. Additionally, prostate tissue from a subset of these patients is highly enriched in MSCs, suggesting their enumeration may have prognostic value for identifying men with aggressive disease. This influx is an ongoing process continuing throughout disease progression as documented by the presence of MSCs in metastatic lesions from multiple organ sites harvested at the time of death in metastatic castration-resistant prostate cancer (mCRPC) patients. This infiltration of MSCs from systemic circulation provides the rationale for their use as a cell-based vector to deliver therapeutic agents.

Original languageEnglish (US)
Pages (from-to)46710-46727
Number of pages18
JournalOncotarget
Volume8
Issue number29
DOIs
StatePublished - 2017

Keywords

  • Benign prostatic hyperplasia
  • Mesenchymal stem cells
  • Prostate cancer
  • Stem/progenitor cell
  • Tissue-specific stem cell

ASJC Scopus subject areas

  • Oncology

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