Mesencephalic cryptococcal abscesses presenting with parkinsonism as an initial manifestation of AIDS

John Paul Bouffard, Hernando Mena, Mary Ripple, Juan Troncoso

Research output: Contribution to journalArticle

Abstract

Parkinsonism has been associated with HIV/AIDS and cerebral cryptococcal disease, but to date there has been no report of histological cryptococcal lesions in the substantia nigra (SN) in a patient with parkinsonism. We report on a case of a 63-year-old man who presented with tremor, gait disturbance, and mask-like facies, and showed cryptococcal meningoencephalitis with cryptococcal abscesses in the SN at autopsy, without Lewy bodies or significant degeneration of the SN neurons. Parkinsonism also represented the first manifestation of AIDS in this previously undiagnosed patient. This case highlights the importance of considering infectious etiologies in patients presenting with parkinsonism, and underscores the need for autopsy in evaluation of patients with new or unexplained movement disorders. Movement disorders in association with AIDS and mesencephalic mass lesions are discussed.

Original languageEnglish (US)
Pages (from-to)1354-1357
Number of pages4
JournalMovement Disorders
Volume18
Issue number11
DOIs
StatePublished - Nov 1 2003

Keywords

  • AIDS
  • CNS
  • Opportunistic Cryptococcus infection
  • Parkinsonism

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Mesencephalic cryptococcal abscesses presenting with parkinsonism as an initial manifestation of AIDS'. Together they form a unique fingerprint.

  • Cite this