Le MEOPA (Kalinox®): Mélange équimolaire oxygène et protoxyde d'azote dans le traitement de la douleur

Translated title of the contribution: MEOPA (Kalinox®): Equimolar mixture of oxygen and nitrogen peroxide for the treatment of pain

Jean Michel Pellat, Hassan Hodaj, Affif Kaddour, Jean Alexandre Long, Jean François Payen, Claude Jacquot, Jean Pierre Alibeu

Research output: Contribution to journalReview articlepeer-review

Abstract

MEOPA is gas mixture with 50% nitrogen protoxide and 50% oxygen. It is widely used for analgesia, particularly for short painful interventions. The low solubility in blood and tissues of nitrogen protoxide produces pharmacokinetic properties leading to rapidly reversible effects. The equimolar formulation with oxygen allows safe use outside the operating room by non-anesthesists and for non-fasting patients. Adverse effect are exceptional and always minor. The mechanisms of the analgesic effects are imperfectly understood but the endogenous opioid system and activation of descending nonadrenergic pathways are involved. We discuss the principal theoretical and practical aspects of MEOPA for the treatment of pain.

Translated title of the contributionMEOPA (Kalinox®): Equimolar mixture of oxygen and nitrogen peroxide for the treatment of pain
Original languageFrench
Pages (from-to)275-281
Number of pages7
JournalDouleurs
Volume5
Issue number5
StatePublished - Oct 2004

Keywords

  • Analgesia
  • Gas mixture
  • Iatrogenic pain
  • MEOPA
  • Nitrogen protoxide
  • Painful interventions

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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