Le MEOPA (Kalinox®): Mélange équimolaire oxygène et protoxyde d'azote dans le traitement de la douleur

Jean Michel Pellat; Hassan Hodaj; Affif Kaddour; Jean Alexandre Long; Jean François Payen; Claude Jacquot; Jean Pierre Alibeu

doi:10.1016/s1624-5687(04)94527-1

Le MEOPA (Kalinox®): Mélange équimolaire oxygène et protoxyde d'azote dans le traitement de la douleur

Translated title of the contribution: MEOPA (Kalinox®): Equimolar mixture of oxygen and nitrogen peroxide for the treatment of pain

Jean Michel Pellat, Hassan Hodaj, Affif Kaddour, Jean Alexandre Long, Jean François Payen, Claude Jacquot, Jean Pierre Alibeu

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

MEOPA is gas mixture with 50% nitrogen protoxide and 50% oxygen. It is widely used for analgesia, particularly for short painful interventions. The low solubility in blood and tissues of nitrogen protoxide produces pharmacokinetic properties leading to rapidly reversible effects. The equimolar formulation with oxygen allows safe use outside the operating room by non-anesthesists and for non-fasting patients. Adverse effect are exceptional and always minor. The mechanisms of the analgesic effects are imperfectly understood but the endogenous opioid system and activation of descending nonadrenergic pathways are involved. We discuss the principal theoretical and practical aspects of MEOPA for the treatment of pain.

Translated title of the contribution	MEOPA (Kalinox®): Equimolar mixture of oxygen and nitrogen peroxide for the treatment of pain
Original language	French
Pages (from-to)	275-281
Number of pages	7
Journal	Douleurs
Volume	5
Issue number	5
DOIs	https://doi.org/10.1016/s1624-5687(04)94527-1
State	Published - Oct 2004
Externally published	Yes

Keywords

Analgesia
Gas mixture
Iatrogenic pain
MEOPA
Nitrogen protoxide
Painful interventions

ASJC Scopus subject areas

Clinical Neurology
Anesthesiology and Pain Medicine

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10.1016/s1624-5687(04)94527-1

Cite this

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title = "Le MEOPA (Kalinox{\textregistered}): M{\'e}lange {\'e}quimolaire oxyg{\`e}ne et protoxyde d'azote dans le traitement de la douleur",

abstract = "MEOPA is gas mixture with 50% nitrogen protoxide and 50% oxygen. It is widely used for analgesia, particularly for short painful interventions. The low solubility in blood and tissues of nitrogen protoxide produces pharmacokinetic properties leading to rapidly reversible effects. The equimolar formulation with oxygen allows safe use outside the operating room by non-anesthesists and for non-fasting patients. Adverse effect are exceptional and always minor. The mechanisms of the analgesic effects are imperfectly understood but the endogenous opioid system and activation of descending nonadrenergic pathways are involved. We discuss the principal theoretical and practical aspects of MEOPA for the treatment of pain.",

keywords = "Analgesia, Gas mixture, Iatrogenic pain, MEOPA, Nitrogen protoxide, Painful interventions",

author = "Pellat, {Jean Michel} and Hassan Hodaj and Affif Kaddour and Long, {Jean Alexandre} and Payen, {Jean Fran{\c c}ois} and Claude Jacquot and Alibeu, {Jean Pierre}",

year = "2004",

month = oct,

doi = "10.1016/s1624-5687(04)94527-1",

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AU - Pellat, Jean Michel

AU - Hodaj, Hassan

AU - Kaddour, Affif

AU - Long, Jean Alexandre

AU - Payen, Jean François

AU - Jacquot, Claude

AU - Alibeu, Jean Pierre

PY - 2004/10

Y1 - 2004/10

N2 - MEOPA is gas mixture with 50% nitrogen protoxide and 50% oxygen. It is widely used for analgesia, particularly for short painful interventions. The low solubility in blood and tissues of nitrogen protoxide produces pharmacokinetic properties leading to rapidly reversible effects. The equimolar formulation with oxygen allows safe use outside the operating room by non-anesthesists and for non-fasting patients. Adverse effect are exceptional and always minor. The mechanisms of the analgesic effects are imperfectly understood but the endogenous opioid system and activation of descending nonadrenergic pathways are involved. We discuss the principal theoretical and practical aspects of MEOPA for the treatment of pain.

AB - MEOPA is gas mixture with 50% nitrogen protoxide and 50% oxygen. It is widely used for analgesia, particularly for short painful interventions. The low solubility in blood and tissues of nitrogen protoxide produces pharmacokinetic properties leading to rapidly reversible effects. The equimolar formulation with oxygen allows safe use outside the operating room by non-anesthesists and for non-fasting patients. Adverse effect are exceptional and always minor. The mechanisms of the analgesic effects are imperfectly understood but the endogenous opioid system and activation of descending nonadrenergic pathways are involved. We discuss the principal theoretical and practical aspects of MEOPA for the treatment of pain.

KW - Analgesia

KW - Gas mixture

KW - Iatrogenic pain

KW - MEOPA

KW - Nitrogen protoxide

KW - Painful interventions

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DO - 10.1016/s1624-5687(04)94527-1

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Le MEOPA (Kalinox®): Mélange équimolaire oxygène et protoxyde d'azote dans le traitement de la douleur

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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