Menthol cigarette smoking in the COPDGene cohort

Relationship with COPD, comorbidities and CT metrics

Seoung Ju Park, Marilyn G. Foreman, Dawn L. Demeo, Surya P. Bhatt, Nadia Hansel, Robert A Wise, Xavier Soler, Russell P. Bowler

Research output: Contribution to journalArticle

Abstract

Background and objective Menthol cigarettes contain higher levels of menthol to produce a characteristic mint flavour and cooling sensation. Compared with non-menthol cigarettes, little information exists on the effects of menthol cigarette smoking on clinical and radiological characteristics of chronic obstructive pulmonary disease (COPD). The main objective of the present study was to examine associations between menthol cigarette use and the risk of COPD and its characteristics, such as exacerbation, comorbidities and computed tomography (CT) abnormalities. Methods We analysed the data from 5699 current smokers in the COPDGene cohort to evaluate whether lung function, comorbidities, exacerbations and CT parameters were different between menthol and non-menthol cigarette smokers. Results There were 3758 (65.9%) who reported use of menthol cigarettes. Multivariable regression analysis revealed that younger age, female gender and African-American ethnicity were significantly associated with smoking of menthol cigarettes. No significant associations were found between menthol cigarette use and COPD, major CT findings or comorbidities, such as cardiovascular disease, congestive heart failure, peripheral vascular disease, cerebrovascular disease, hypertension, diabetes, gastro-oesophageal reflux and osteoporosis; however, menthol cigarette smokers were more likely to experience a severe exacerbation of COPD during longitudinal follow-up (odds ratio 1.29; 95% confidence interval: 1.01-1.54) compared with the non-menthol cigarette smokers. Conclusions These results confirm that menthol cigarettes are not safer than traditional cigarettes and suggest that menthol cigarette smokers may have more frequent severe exacerbations than non-menthol cigarette smokers. Little information exists on the effects of menthol cigarette smoking on clinical and radiological characteristics of chronic obstructive pulmonary disease (COPD). Our results confirm that menthol cigarettes are not safer than traditional cigarettes and suggest that menthol cigarette smokers may have more frequent severe exacerbations than non-menthol cigarette smokers.

Original languageEnglish (US)
Pages (from-to)108-114
Number of pages7
JournalRespirology
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2015

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Menthol
Tobacco Products
Chronic Obstructive Pulmonary Disease
Comorbidity
Smoking
Tomography
Mentha
Cerebrovascular Disorders
Peripheral Vascular Diseases

Keywords

  • chronic obstructive pulmonary disease
  • computed tomography
  • exacerbation
  • menthol
  • smoking

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Menthol cigarette smoking in the COPDGene cohort : Relationship with COPD, comorbidities and CT metrics. / Park, Seoung Ju; Foreman, Marilyn G.; Demeo, Dawn L.; Bhatt, Surya P.; Hansel, Nadia; Wise, Robert A; Soler, Xavier; Bowler, Russell P.

In: Respirology, Vol. 20, No. 1, 01.01.2015, p. 108-114.

Research output: Contribution to journalArticle

Park, Seoung Ju ; Foreman, Marilyn G. ; Demeo, Dawn L. ; Bhatt, Surya P. ; Hansel, Nadia ; Wise, Robert A ; Soler, Xavier ; Bowler, Russell P. / Menthol cigarette smoking in the COPDGene cohort : Relationship with COPD, comorbidities and CT metrics. In: Respirology. 2015 ; Vol. 20, No. 1. pp. 108-114.
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abstract = "Background and objective Menthol cigarettes contain higher levels of menthol to produce a characteristic mint flavour and cooling sensation. Compared with non-menthol cigarettes, little information exists on the effects of menthol cigarette smoking on clinical and radiological characteristics of chronic obstructive pulmonary disease (COPD). The main objective of the present study was to examine associations between menthol cigarette use and the risk of COPD and its characteristics, such as exacerbation, comorbidities and computed tomography (CT) abnormalities. Methods We analysed the data from 5699 current smokers in the COPDGene cohort to evaluate whether lung function, comorbidities, exacerbations and CT parameters were different between menthol and non-menthol cigarette smokers. Results There were 3758 (65.9{\%}) who reported use of menthol cigarettes. Multivariable regression analysis revealed that younger age, female gender and African-American ethnicity were significantly associated with smoking of menthol cigarettes. No significant associations were found between menthol cigarette use and COPD, major CT findings or comorbidities, such as cardiovascular disease, congestive heart failure, peripheral vascular disease, cerebrovascular disease, hypertension, diabetes, gastro-oesophageal reflux and osteoporosis; however, menthol cigarette smokers were more likely to experience a severe exacerbation of COPD during longitudinal follow-up (odds ratio 1.29; 95{\%} confidence interval: 1.01-1.54) compared with the non-menthol cigarette smokers. Conclusions These results confirm that menthol cigarettes are not safer than traditional cigarettes and suggest that menthol cigarette smokers may have more frequent severe exacerbations than non-menthol cigarette smokers. Little information exists on the effects of menthol cigarette smoking on clinical and radiological characteristics of chronic obstructive pulmonary disease (COPD). Our results confirm that menthol cigarettes are not safer than traditional cigarettes and suggest that menthol cigarette smokers may have more frequent severe exacerbations than non-menthol cigarette smokers.",
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AU - Foreman, Marilyn G.

AU - Demeo, Dawn L.

AU - Bhatt, Surya P.

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AU - Wise, Robert A

AU - Soler, Xavier

AU - Bowler, Russell P.

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AB - Background and objective Menthol cigarettes contain higher levels of menthol to produce a characteristic mint flavour and cooling sensation. Compared with non-menthol cigarettes, little information exists on the effects of menthol cigarette smoking on clinical and radiological characteristics of chronic obstructive pulmonary disease (COPD). The main objective of the present study was to examine associations between menthol cigarette use and the risk of COPD and its characteristics, such as exacerbation, comorbidities and computed tomography (CT) abnormalities. Methods We analysed the data from 5699 current smokers in the COPDGene cohort to evaluate whether lung function, comorbidities, exacerbations and CT parameters were different between menthol and non-menthol cigarette smokers. Results There were 3758 (65.9%) who reported use of menthol cigarettes. Multivariable regression analysis revealed that younger age, female gender and African-American ethnicity were significantly associated with smoking of menthol cigarettes. No significant associations were found between menthol cigarette use and COPD, major CT findings or comorbidities, such as cardiovascular disease, congestive heart failure, peripheral vascular disease, cerebrovascular disease, hypertension, diabetes, gastro-oesophageal reflux and osteoporosis; however, menthol cigarette smokers were more likely to experience a severe exacerbation of COPD during longitudinal follow-up (odds ratio 1.29; 95% confidence interval: 1.01-1.54) compared with the non-menthol cigarette smokers. Conclusions These results confirm that menthol cigarettes are not safer than traditional cigarettes and suggest that menthol cigarette smokers may have more frequent severe exacerbations than non-menthol cigarette smokers. Little information exists on the effects of menthol cigarette smoking on clinical and radiological characteristics of chronic obstructive pulmonary disease (COPD). Our results confirm that menthol cigarettes are not safer than traditional cigarettes and suggest that menthol cigarette smokers may have more frequent severe exacerbations than non-menthol cigarette smokers.

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KW - exacerbation

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