Mental neuropathy (numb chin syndrome)

A harbinger of tumor progression or relapse

R. K. Burt, William Sharfman, B. I. Karp, W. H. Wilson

Research output: Contribution to journalArticle

Abstract

The authors report four patients whose initial symptom of tumor recurrence or progression was unilateral numbness of the chin. Two patients had Hodgkin lymphoma, one had malignant melanoma, and one had prostate cancer. Physical examination was notable only for unilateral anesthesia of the chin and lower lip. Diagnostic evaluation, including computed tomography (CT) scan and magnetic resonance imaging (MRI) of the brain, plain radiographs of the mandible, and cerebrospinal fluid analysis for protein, glucose, and cytology were normal. Bone scans revealed osseous lesions in the axial skeleton of all patients, whereas only two patients had abnormal uptake in the mandible. The authors conclude that in the setting of a negative evaluation for central nervous system (CNS) or local mandibular disease, mental neuropathy is associated with recurrent or progressive skeletal disease. In addition, to document relapsed or progressive cancer, the skeletal system may have to be examined at sites distant from the mandible.

Original languageEnglish (US)
Pages (from-to)877-881
Number of pages5
JournalCancer
Volume70
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

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Chin
Mandible
Recurrence
Mandibular Diseases
Neoplasms
Cerebrospinal Fluid Proteins
Hypesthesia
Lip
Hodgkin Disease
Skeleton
Physical Examination
Cell Biology
Melanoma
Prostatic Neoplasms
Anesthesia
Central Nervous System
Tomography
Magnetic Resonance Imaging
Bone and Bones
Glucose

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mental neuropathy (numb chin syndrome) : A harbinger of tumor progression or relapse. / Burt, R. K.; Sharfman, William; Karp, B. I.; Wilson, W. H.

In: Cancer, Vol. 70, No. 4, 1992, p. 877-881.

Research output: Contribution to journalArticle

Burt, R. K. ; Sharfman, William ; Karp, B. I. ; Wilson, W. H. / Mental neuropathy (numb chin syndrome) : A harbinger of tumor progression or relapse. In: Cancer. 1992 ; Vol. 70, No. 4. pp. 877-881.
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