Menstrual cycle phase and single tablet antiretroviral medication adherence in women with HIV

Nancy A. Hessol, Susan Holman, Howard Minkoff, Mardge H. Cohen, Elizabeth Golub, Seble Kassaye, Roksana Karim, Oluwakemi Sosanya, Christopher Shaheen, Zaher Merhi

Research output: Contribution to journalArticle

Abstract

Suboptimal adherence to antiretroviral (ARV) therapy among HIV-infected individuals is associated with increased risk of progression to AIDS and the development of HIV resistance to ARV medications. To examine whether the luteal phase of the menstrual cycle is independently associated with suboptimal adherence to single tablet regimen (STR) ARV medication, data were analyzed from a multicenter cohort study of HIV-infected women who reported regular menstrual cycles and were taking an STR. In a cross-sectional analysis, suboptimal adherence to an STR among women in their follicular phase was compared with suboptimal adherence among women in their luteal phase. In two-way crossover analyses, whereby the same woman was assessed for STR medication adherence in both her follicular and luteal phases, the estimated exact conditional odds of non-adherence to an STR was measured. In adjusted logistic regression analysis of the cross-sectional data (N=327), women with ≤12 years of education were more than three times more likely to have suboptimal adherence (OR=3.6, p=.04) compared to those with >12 years of education. Additionally, women with Center for Epidemiological Studies Depression Scale (CES-D) scores ≥23 were 2.5-times more likely to have suboptimal adherence (OR=2.6, p=.02) compared to those with CES-D scores

Original languageEnglish (US)
Pages (from-to)11-21
Number of pages11
JournalAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
Volume28
Issue number1
DOIs
StatePublished - Jan 2 2016

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Medication Adherence
Menstrual Cycle
Tablets
medication
HIV
Luteal Phase
Follicular Phase
Epidemiologic Studies
Depression
Education
Multicenter Studies
education
regression analysis
Acquired Immunodeficiency Syndrome
AIDS
Cohort Studies
Cross-Sectional Studies
Logistic Models
logistics
Regression Analysis

Keywords

  • HIV
  • medication adherence
  • menstrual phase
  • women

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health(social science)
  • Social Psychology

Cite this

Menstrual cycle phase and single tablet antiretroviral medication adherence in women with HIV. / Hessol, Nancy A.; Holman, Susan; Minkoff, Howard; Cohen, Mardge H.; Golub, Elizabeth; Kassaye, Seble; Karim, Roksana; Sosanya, Oluwakemi; Shaheen, Christopher; Merhi, Zaher.

In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, Vol. 28, No. 1, 02.01.2016, p. 11-21.

Research output: Contribution to journalArticle

Hessol, NA, Holman, S, Minkoff, H, Cohen, MH, Golub, E, Kassaye, S, Karim, R, Sosanya, O, Shaheen, C & Merhi, Z 2016, 'Menstrual cycle phase and single tablet antiretroviral medication adherence in women with HIV', AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, vol. 28, no. 1, pp. 11-21. https://doi.org/10.1080/09540121.2015.1069787
Hessol, Nancy A. ; Holman, Susan ; Minkoff, Howard ; Cohen, Mardge H. ; Golub, Elizabeth ; Kassaye, Seble ; Karim, Roksana ; Sosanya, Oluwakemi ; Shaheen, Christopher ; Merhi, Zaher. / Menstrual cycle phase and single tablet antiretroviral medication adherence in women with HIV. In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV. 2016 ; Vol. 28, No. 1. pp. 11-21.
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