Meningorectal fistula as a cause of polymicrobial anaerobic meningitis

T. J. Walsh, R. A. Weinstein, H. Malinoff, M. D. Breyer, B. A. Berelowitz

Research output: Contribution to journalArticle


A 49-year-old diabetic woman developed polymicrobial anaerobic meningitis secondary to a meningorectal fistula one year after receiving neutron beam therapy for a rectal adenocarcinoma. The meningitis was refractory to chloramphenicol and penicillin but responded to oral metronidazole. Sustained eradication of meningitis was achieved with continued metronidazole for 5 1/2 months, despite persistence of the fistula. Metronidazole may be a superior antimicrobial agent for polymicrobial anaerobic meningitis, especially when caused by a large or continuing bacterial inoculum. This meningorectal fistula is the first of its kind to our knowledge to be demonstrated by microbiologic, radiologic, and pathologic studies.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalAmerican Journal of Clinical Pathology
Issue number1
Publication statusPublished - 1982
Externally publishedYes


ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Walsh, T. J., Weinstein, R. A., Malinoff, H., Breyer, M. D., & Berelowitz, B. A. (1982). Meningorectal fistula as a cause of polymicrobial anaerobic meningitis. American Journal of Clinical Pathology, 78(1), 127-130.