Meningitis-associated Escherichia coli

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

E. coli is the most common Gram-negative organism causing neonatal meningitis and neonatal meningitis continues to be an important cause of mortality and morbidity throughout the world. Our incomplete knowledge of its pathogenesis and pathophysiology contributes to such mortality and morbidity. Recent reports of neonatal meningitis caused by E. coli strains producing CTX-M-type or TEM-type extended-spectrum β-lactamases create a challenge. E. coli invasion of the blood-brain barrier is a prerequisite for penetration into the brain, and requires specific microbial-host factors as well as microbe- and host-specific signaling molecules. Blockade of such microbial-host factors and host cell signaling molecules is shown to be efficient in preventing E. coli penetration into the brain, the essential step in the development of E. coli meningitis. Continued investigation of the microbial and host factors contributing to E. coli invasion of the blood-brain barrier is likely to identify new targets for prevention and therapy of E. coli meningitis, thereby limiting the exposure to emerging antimicrobial-resistant E. coli.

Original languageEnglish (US)
Title of host publicationEscherichia coli: Pathotypes and Principles of Pathogenesis: Second Edition
PublisherElsevier Inc.
Pages305-330
Number of pages26
ISBN (Print)9780123970480
DOIs
StatePublished - Aug 5 2013

Fingerprint

Escherichia coli Meningitis
Escherichia coli
Blood-Brain Barrier
Meningitis
Morbidity
Mortality
Brain

Keywords

  • Antibiotic resistance
  • Bacterial binding to and invasion of human brain microvascular endothelial cell monolayer
  • Blood-brain barrier
  • E. coli meningitis
  • Functional genomics
  • Microbial-host factors
  • Prevention of meningitis

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Kim, K. S. (2013). Meningitis-associated Escherichia coli. In Escherichia coli: Pathotypes and Principles of Pathogenesis: Second Edition (pp. 305-330). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-397048-0.00010-3

Meningitis-associated Escherichia coli. / Kim, Kwang Sik.

Escherichia coli: Pathotypes and Principles of Pathogenesis: Second Edition. Elsevier Inc., 2013. p. 305-330.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kim, KS 2013, Meningitis-associated Escherichia coli. in Escherichia coli: Pathotypes and Principles of Pathogenesis: Second Edition. Elsevier Inc., pp. 305-330. https://doi.org/10.1016/B978-0-12-397048-0.00010-3
Kim KS. Meningitis-associated Escherichia coli. In Escherichia coli: Pathotypes and Principles of Pathogenesis: Second Edition. Elsevier Inc. 2013. p. 305-330 https://doi.org/10.1016/B978-0-12-397048-0.00010-3
Kim, Kwang Sik. / Meningitis-associated Escherichia coli. Escherichia coli: Pathotypes and Principles of Pathogenesis: Second Edition. Elsevier Inc., 2013. pp. 305-330
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