TY - JOUR
T1 - Mendelian randomization analysis as a tool to gain insights into causes of diseases
T2 - A primer
AU - Tin, Adrienne
AU - Kottgen, Anna
N1 - Funding Information:
The work of A. Ko€ttgen has been funded by the Deutsche Forschungsge-meinschaft (DFG, German Research Foundation) – Project-ID 431984000 – SFB 1453.
Publisher Copyright:
Copyright ß 2021 by the American Society of Nephrology
PY - 2021/10
Y1 - 2021/10
N2 - Many Mendelian randomization (MR) studies have been published recently, with inferences on the causal relationships between risk factors and diseases that have potential implications for clinical research. In nephrology, MR methods have been applied to investigate potential causal relationships of traditional risk factors, lifestyle factors, and biomarkers from omics technologies with kidney function or CKD. This primer summarizes the basic concepts of MR studies, highlighting methods used in recent applications, and emphasizes key elements in conducting and reporting of MR studies that are important for interpreting the results.
AB - Many Mendelian randomization (MR) studies have been published recently, with inferences on the causal relationships between risk factors and diseases that have potential implications for clinical research. In nephrology, MR methods have been applied to investigate potential causal relationships of traditional risk factors, lifestyle factors, and biomarkers from omics technologies with kidney function or CKD. This primer summarizes the basic concepts of MR studies, highlighting methods used in recent applications, and emphasizes key elements in conducting and reporting of MR studies that are important for interpreting the results.
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U2 - 10.1681/ASN.2020121760
DO - 10.1681/ASN.2020121760
M3 - Review article
C2 - 34135084
AN - SCOPUS:85111907685
SN - 1046-6673
VL - 32
SP - 2400
EP - 2407
JO - Journal of the American Society of Nephrology
JF - Journal of the American Society of Nephrology
IS - 10
ER -