Mendelian disorders and multifactorial traits: The big divide or one for all?

Stylianos E. Antonarakis, Aravinda Chakravarti, Jonathan C. Cohen, John Hardy

Research output: Contribution to journalArticle

Abstract

For the past century, Mendelian and multifactorial traits have existed at opposite ends of the disease spectrum in humans. Furthermore, the recent emphasis on genome-wide association studies for uncovering variants that underlie common diseases has risked deepening the divide ĝ€" or has it? Four experienced human geneticists express their views on the changing landscape of human disease studies and the impact of new technologies and study designs on the age-old aim of connecting a genomic variant with its phenotypic consequences.

Original languageEnglish (US)
Pages (from-to)380-384
Number of pages5
JournalNature Reviews Genetics
Volume11
Issue number5
DOIs
StatePublished - May 2010

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Genome-Wide Association Study
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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Molecular Biology

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Antonarakis, S. E., Chakravarti, A., Cohen, J. C., & Hardy, J. (2010). Mendelian disorders and multifactorial traits: The big divide or one for all? Nature Reviews Genetics, 11(5), 380-384. https://doi.org/10.1038/nrg2793

Mendelian disorders and multifactorial traits : The big divide or one for all? / Antonarakis, Stylianos E.; Chakravarti, Aravinda; Cohen, Jonathan C.; Hardy, John.

In: Nature Reviews Genetics, Vol. 11, No. 5, 05.2010, p. 380-384.

Research output: Contribution to journalArticle

Antonarakis, SE, Chakravarti, A, Cohen, JC & Hardy, J 2010, 'Mendelian disorders and multifactorial traits: The big divide or one for all?', Nature Reviews Genetics, vol. 11, no. 5, pp. 380-384. https://doi.org/10.1038/nrg2793
Antonarakis, Stylianos E. ; Chakravarti, Aravinda ; Cohen, Jonathan C. ; Hardy, John. / Mendelian disorders and multifactorial traits : The big divide or one for all?. In: Nature Reviews Genetics. 2010 ; Vol. 11, No. 5. pp. 380-384.
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