Mendelian disorders and multifactorial traits: The big divide or one for all?

Stylianos E. Antonarakis, Aravinda Chakravarti, Jonathan C. Cohen, John Hardy

Research output: Contribution to journalReview article

Abstract

For the past century, Mendelian and multifactorial traits have existed at opposite ends of the disease spectrum in humans. Furthermore, the recent emphasis on genome-wide association studies for uncovering variants that underlie common diseases has risked deepening the divide ĝ€" or has it? Four experienced human geneticists express their views on the changing landscape of human disease studies and the impact of new technologies and study designs on the age-old aim of connecting a genomic variant with its phenotypic consequences.

Original languageEnglish (US)
Pages (from-to)380-384
Number of pages5
JournalNature Reviews Genetics
Volume11
Issue number5
DOIs
StatePublished - May 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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