Memories of lost enhancers

Ranjan Sen, Rudolf Grosschedl

Research output: Contribution to journalArticle

Abstract

Transcriptional enhancers are key determinants of developmentally regulated gene expression. Models of enhancer function must distinguish between analog or digital control of transcription, as well as their requirement to initiate or maintain transcriptional activity of a gene. In light of a recent study by Chong and colleagues (pp. 659-669) providing evidence of a transient requirement of an enhancer associated with the CD4 gene, we discuss possible mechanisms by which transcriptional memory can be propagated in the absence of enhancers.

Original languageEnglish (US)
Pages (from-to)973-979
Number of pages7
JournalGenes & development
Volume24
Issue number10
DOIs
StatePublished - May 15 2010
Externally publishedYes

Keywords

  • CD4
  • Chromatin
  • Epigenetics
  • Gene regulation
  • T-cell development
  • Transcription

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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  • Cite this

    Sen, R., & Grosschedl, R. (2010). Memories of lost enhancers. Genes & development, 24(10), 973-979. https://doi.org/10.1101/gad.1930610