Memories of lost enhancers

Ranjan Sen; Rudolf Grosschedl

doi:10.1101/gad.1930610

Memories of lost enhancers

Ranjan Sen, Rudolf Grosschedl

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Transcriptional enhancers are key determinants of developmentally regulated gene expression. Models of enhancer function must distinguish between analog or digital control of transcription, as well as their requirement to initiate or maintain transcriptional activity of a gene. In light of a recent study by Chong and colleagues (pp. 659-669) providing evidence of a transient requirement of an enhancer associated with the CD4 gene, we discuss possible mechanisms by which transcriptional memory can be propagated in the absence of enhancers.

Original language	English (US)
Pages (from-to)	973-979
Number of pages	7
Journal	Genes & development
Volume	24
Issue number	10
DOIs	https://doi.org/10.1101/gad.1930610
State	Published - May 15 2010
Externally published	Yes

Keywords

CD4
Chromatin
Epigenetics
Gene regulation
T-cell development
Transcription

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.1930610

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KW - Epigenetics

KW - Gene regulation

KW - T-cell development

KW - Transcription

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Memories of lost enhancers

Abstract

Keywords

ASJC Scopus subject areas

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