Membranous glomerulopathy associated with graft-versus-host disease following allogeneic stem cell transplantation: Report of 2 cases and review of the literature

Julie Lin, Glen S. Markowitz, Maria Nicolaides, Charles S. Hesdorffer, Gerald B. Appel, Vivette D. D'Agati, David G. Savage

Research output: Contribution to journalArticlepeer-review

Abstract

We report two cases of nephrotic syndrome presenting 18 and 20 months after allogeneic stem cell transplantation (alloSCT) with chronic myelogenous leukemia. Both patients had acute and chronic graft-versus-host disease (GVHD) and renal biopsy findings of membranous glomerulopathy (MG). A review of the literature revealed 10 additional cases of immune-complex-mediated glomerular disease following alloSCT, 8 of which were diagnostic of MG. All patients showed evidence of acute or chronic GVHD. Patients typically presented with preserved renal function (mean creatinine 1.2 mg/dl) and full nephrotic syndrome including heavy proteinuria (mean 9.2 g/24 h), edema, hypoalbuminemia (mean 2.1 g/dl) and hypercholesterolemia (mean 472 mg/dl). Most patients showed stabilization of renal function and significant decreases in proteinuria when treated with steroids and/or cyclosporine. The close temporal association as well as evidence from murine models of GVHD support a pathogenetic association between GVHD and the development of MG.

Original languageEnglish (US)
Pages (from-to)351-356
Number of pages6
JournalAmerican Journal of Nephrology
Volume21
Issue number5
DOIs
StatePublished - Dec 1 2001

Keywords

  • Allogeneic transplantation
  • Bone marrow transplantation
  • Graft-versus-host disease
  • Membranous glomerulopathy

ASJC Scopus subject areas

  • Nephrology

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