Abstract
We report two cases of nephrotic syndrome presenting 18 and 20 months after allogeneic stem cell transplantation (alloSCT) with chronic myelogenous leukemia. Both patients had acute and chronic graft-versus-host disease (GVHD) and renal biopsy findings of membranous glomerulopathy (MG). A review of the literature revealed 10 additional cases of immune-complex-mediated glomerular disease following alloSCT, 8 of which were diagnostic of MG. All patients showed evidence of acute or chronic GVHD. Patients typically presented with preserved renal function (mean creatinine 1.2 mg/dl) and full nephrotic syndrome including heavy proteinuria (mean 9.2 g/24 h), edema, hypoalbuminemia (mean 2.1 g/dl) and hypercholesterolemia (mean 472 mg/dl). Most patients showed stabilization of renal function and significant decreases in proteinuria when treated with steroids and/or cyclosporine. The close temporal association as well as evidence from murine models of GVHD support a pathogenetic association between GVHD and the development of MG.
Original language | English (US) |
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Pages (from-to) | 351-356 |
Number of pages | 6 |
Journal | American Journal of Nephrology |
Volume | 21 |
Issue number | 5 |
DOIs | |
State | Published - Dec 1 2001 |
Keywords
- Allogeneic transplantation
- Bone marrow transplantation
- Graft-versus-host disease
- Membranous glomerulopathy
ASJC Scopus subject areas
- Nephrology