TY - JOUR
T1 - Membrane shape-mediated wave propagation of cortical protein dynamics
AU - Wu, Zhanghan
AU - Su, Maohan
AU - Tong, Cheesan
AU - Wu, Min
AU - Liu, Jian
N1 - Funding Information:
We would like to thank Michael Sheetz for suggesting the deoxycholate experiment, Yang Yang and Ding Xiong for sharing experimental results, and Emma Feng and Larry Cheung for technical assistance. We also thank Jonathan Silver for critical reading and editing. This work was supported by the intramural research program of NHLBI at NIH (J.L.) and the National Research Foundation (NRF) Singapore under its NRF Fellowship Programme (M.W., NRF Award No: NRF-NRFF2011-09).
Publisher Copyright:
© 2017 The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Immune cells exhibit stimulation-dependent traveling waves in the cortex, much faster than typical cortical actin waves. These waves reflect rhythmic assembly of both actin machinery and peripheral membrane proteins such as F-BAR domain-containing proteins. Combining theory and experiments, we develop a mechanochemical feedback model involving membrane shape changes and F-BAR proteins that render the cortex an interesting dynamical system. We show that such cortical dynamics manifests itself as ultrafast traveling waves of cortical proteins, in which the curvature sensitivity-driven feedback always constrains protein lateral diffusion in wave propagation. The resulting protein wave propagation mainly reflects the spatial gradient in the timing of local protein recruitment from cytoplasm. We provide evidence that membrane undulations accompany these protein waves and potentiate their propagation. Therefore, membrane shape change and protein curvature sensitivity may have underappreciated roles in setting high-speed cortical signal transduction rhythms.
AB - Immune cells exhibit stimulation-dependent traveling waves in the cortex, much faster than typical cortical actin waves. These waves reflect rhythmic assembly of both actin machinery and peripheral membrane proteins such as F-BAR domain-containing proteins. Combining theory and experiments, we develop a mechanochemical feedback model involving membrane shape changes and F-BAR proteins that render the cortex an interesting dynamical system. We show that such cortical dynamics manifests itself as ultrafast traveling waves of cortical proteins, in which the curvature sensitivity-driven feedback always constrains protein lateral diffusion in wave propagation. The resulting protein wave propagation mainly reflects the spatial gradient in the timing of local protein recruitment from cytoplasm. We provide evidence that membrane undulations accompany these protein waves and potentiate their propagation. Therefore, membrane shape change and protein curvature sensitivity may have underappreciated roles in setting high-speed cortical signal transduction rhythms.
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U2 - 10.1038/s41467-017-02469-1
DO - 10.1038/s41467-017-02469-1
M3 - Article
C2 - 29321558
AN - SCOPUS:85040511161
SN - 2041-1723
VL - 9
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 136
ER -