Membrane myopathy: Morphological similarities to Duchenne muscular dystrophy

A. Pestronk, I. M. Parhad, Daniel B Drachman, D. L. Price

Research output: Contribution to journalArticle

Abstract

Focal lesions in the plasma membrane overlying wedge-shaped defects in muscle fibers ('delta lesions') are an early pathological change in Duchenne muscular dystrophy (DMD). Abnormalities in the plasma membrane have been suggested as a cause of these lesions and of the degeneration of muscle fibers in DMD. We investigated the role of plasma membrane defects in the production of delta lesions by examining the effects of a series of membrane-active agents - lysolecithin, deoxycholate, Triton X-100, and melittin - on the muscles of rats in vivo. Within minutes after treatment with these agents, the muscle fibers developed typical delta lesions. Identical morphological changes were produced by the calcium ionophore A23187, suggesting that calcium entry may play an important role in this process. We conclude that damage to the plasma membrane or calcium entry can reproduce characteristic features of the muscle pathology seen in DMD. This model should prove useful in elucidating the mechanisms of muscle fiber damage and degeneration in DMD.

Original languageEnglish (US)
Pages (from-to)209-214
Number of pages6
JournalMuscle and Nerve
Volume5
Issue number3
StatePublished - 1982

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Duchenne Muscular Dystrophy
Muscular Diseases
Muscles
Membranes
Cell Membrane
Melitten
Calcium
Lysophosphatidylcholines
Deoxycholic Acid
Calcium Ionophores
Calcimycin
Octoxynol
Pathology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Membrane myopathy : Morphological similarities to Duchenne muscular dystrophy. / Pestronk, A.; Parhad, I. M.; Drachman, Daniel B; Price, D. L.

In: Muscle and Nerve, Vol. 5, No. 3, 1982, p. 209-214.

Research output: Contribution to journalArticle

Pestronk, A, Parhad, IM, Drachman, DB & Price, DL 1982, 'Membrane myopathy: Morphological similarities to Duchenne muscular dystrophy', Muscle and Nerve, vol. 5, no. 3, pp. 209-214.
Pestronk, A. ; Parhad, I. M. ; Drachman, Daniel B ; Price, D. L. / Membrane myopathy : Morphological similarities to Duchenne muscular dystrophy. In: Muscle and Nerve. 1982 ; Vol. 5, No. 3. pp. 209-214.
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